DWA1 DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DWA1
Official Full Name: DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1
Primary source: TAIR:AT2G19430
Locus tag: AT2G19430
See related: Araport:AT2G19430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtTHO6; DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1; F27F23.25; THO6
Summary: This gene is predicted to encode a protein with a DWD motif. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase. Encodes a component of the putative Arabidopsis THO/TREX complex: THO1 or HPR1 (At5g09860), THO2 (At1g24706), THO3 or TEX1 (At5g56130), THO5 (At5g42920, At1g45233), THO6 (At2g19430), and THO7 (At5g16790, At3g02950). THO/TREX complexes in animals have been implicated in the transport of mRNA precursors. Mutants of THO3/TEX1, THO1, THO6 accumulate reduced amount of small interfering (si)RNA, suggesting a role of the putative Arabidopsis THO/TREX in siRNA biosynthesis.
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Genomic context

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See DWA1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 11

Sequence:: Chromosome: 2; NC_003071.7 (8415046..8417994)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DWA1 and DWA2 interact with DDB1 and ABI5 to negatively regulate abscisic acid signal transduction.
Title: DWA1 and DWA2, two Arabidopsis DWD protein components of CUL4-based E3 ligases, act together as negative regulators in ABA signal transduction.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_179658.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ta-siRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of THO complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1

NP_849989.1

DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1 (DWA1); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT3G49660.1); Has 25005 Blast hits to 14147 proteins in 619 species: Archae - 64; Bacteria - 4449; Metazoa - 9459; Fungi - 5655; Plants - 2500; Viruses - 0; Other Eukaryotes - 2878 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

8415046..8417994

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_179658.4 → NP_849989.1 DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849989.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O64576, Q8L4M1

UniProtKB/TrEMBL

A0A178W1M2, A0A5S9WZA4, A0A7G2EDJ0

Conserved Domains (2) summary

sd00039
Location:163 → 199

7WD40; WD40 repeat [structural motif]

cl29593
Location:40 → 306

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...