TSPO TSPO(outer membrane tryptophan-rich sensory protein)-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TSPO
Official Full Name: TSPO(outer membrane tryptophan-rich sensory protein)-like protein
Primary source: TAIR:AT2G47770
Locus tag: AT2G47770
See related: Araport:AT2G47770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATTSPO; F17A22.16; TSPO(outer membrane tryptophan-rich sensory protein)-related
Summary: Encodes a membrane-bound protein designated AtTSPO (Arabidopsis thaliana TSPO-related). AtTSPO is related to the bacterial outer membrane tryptophan-rich sensory protein (TspO) and the mammalian mitochondrial 18 kDa Translocator Protein (18 kDa TSPO), members of the TspO/MBR domain-containing membrane proteins. Mainly detected in dry seeds, but can be induced in vegetative tissues by osmotic or salt stress or abscisic acid treatment. Located in endoplasmic reticulum and the Golgi stacks. It is degraded through the autophagy pathway.
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Genomic context

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See TSPO in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (19568464..19569507)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Possible crosstalk between the Arabidopsis TSPO-related protein and the transcription factor WRINKLED1.
Title: Possible crosstalk between the Arabidopsis TSPO-related protein and the transcription factor WRINKLED1.
TSPO physically interacts with PIP2;7 at the endoplasmic reticulum and Golgi membranes.
Title: The Arabidopsis abiotic stress-induced TSPO-related protein reduces cell-surface expression of the aquaporin PIP2;7 through protein-protein interactions and autophagic degradation.
The arabidopsis TSPO (translocator protein)-related protein is transiently induced by abiotic stresses and ABA treatment.
Title: Arabidopsis TSPO and porphyrins metabolism: a transient signaling connection?
AtTSPO can localize to endoplasmic reticulum and mitochondria, but when plants are salt stressed AtTSPO is found in chloroplasts.
Title: The Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.
At-TSPO is a heme binding membrane protein; its downregulation by plant cells requires heme binding.
Title: The Arabidopsis multistress regulator TSPO is a heme binding membrane protein and a potential scavenger of porphyrins via an autophagy-dependent degradation mechanism.
AtTSPO is targeted to the endoplasmic reticulum in plant cells and accumulates in the Trans-Golgi Network.
Title: A TSPO-related protein localizes to the early secretory pathway in Arabidopsis, but is targeted to mitochondria when expressed in yeast.
AtTSPO is expressed in dry seeds and can be induced in vegetative tissues by osmotic and salt stress or abscisic acid (ABA) treatment. [AtTSPO]
Title: ABA, porphyrins and plant TSPO-related protein.
TSPO-related protein is expression localized to the endoplasmic reticulum and Golgi apparatus, and its expression is regulated by stress and abscisic acid.
Title: The Arabidopsis TSPO-related protein is a stress and abscisic acid-regulated, endoplasmic reticulum-Golgi-localized membrane protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_130344.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables heme binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within porphyrin-containing compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi stack	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: TSPO(outer membrane tryptophan-rich sensory protein)-like protein

NP_566110.1

TSPO(outer membrane tryptophan-rich sensory protein)-related (TSPO); CONTAINS InterPro DOMAIN/s: TspO/MBR-related protein (InterPro:IPR004307); Has 567 Blast hits to 567 proteins in 188 species: Archae - 24; Bacteria - 226; Metazoa - 151; Fungi - 6; Plants - 53; Viruses - 0; Other Eukaryotes - 107 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

19568464..19569507

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130344.2 → NP_566110.1 TSPO(outer membrane tryptophan-rich sensory protein)-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566110.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O82245

UniProtKB/TrEMBL

A0A178W1Q1, A0A5S9X8E2, A0A654F811

Conserved Domains (1) summary

cd15904
Location:50 → 190

TSPO_MBR; Translocator protein (TSPO)/peripheral-type benzodiazepine receptor (MBR) family