PDIL1-1 PDI-like 1-1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: PDIL1-1
Official Full Name: PDI-like 1-1
Primary source: TAIR:AT1G21750
Locus tag: AT1G21750
See related: Araport:AT1G21750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA PROTEIN DISULFIDE ISOMERASE 5; ATPDI5; ATPDIL1-1; F8K7.19; F8K7_19; PDI-like 1-1; PDI5; PROTEIN DISULFIDE ISOMERASE 5
Summary: Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily; isoform contains non-consensus GA donor splice site at intron 9. Transcript levels for this gene are up-regulated in response to three different chemical inducers of ER stress (dithiothreitol, beta-mercaptoethanol, and tunicamycin). Neither AtIRE1-2 nor AtbZIP60 appear to be required for this response.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See PDIL1-1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 9

Sequence:: Chromosome: 1; NC_003070.9 (7645610..7648855)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AFL1, PDI5, and NAI2 are involved in drought signaling in Arabidopsis thaliana
Title: At14a-Like1 participates in membrane-associated mechanisms promoting growth during drought in Arabidopsis thaliana.
Data suggest that PDI5 is required for proper seed development and regulates the timing of PCD by chaperoning and inhibiting Cys proteases during their trafficking to vacuoles before PCD of the endothelial cells. [PDI5]
Title: Arabidopsis protein disulfide isomerase-5 inhibits cysteine proteases during trafficking to vacuoles before programmed cell death of the endothelium in developing seeds.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_102024.4

Supported by ESTs:

NM_179365.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein disulfide isomerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within seed development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in lytic vacuole within protein storage vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in protein storage vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in secretory vesicle	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: PDI-like 1-1

NP_173594.1

PDI-like 1-1 (PDIL1-1); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: in 6 processes; LOCATED IN: in 8 components; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Disulphide isomerase (InterPro:IPR005788), Thioredoxin fold (InterPro:IPR012335), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Protein disulphide isomerase (InterPro:IPR005792), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: PDI-like 1-2 (TAIR:AT1G77510.1); Has 31573 Blast hits to 17834 proteins in 2924 species: Archae - 337; Bacteria - 15428; Metazoa - 5451; Fungi - 1644; Plants - 2422; Viruses - 29; Other Eukaryotes - 6262 (source: NCBI BLink).

NP_849696.1

PDI-like 1-1 (PDIL1-1); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: in 6 processes; LOCATED IN: in 8 components; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Disulphide isomerase (InterPro:IPR005788), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Protein disulphide isomerase (InterPro:IPR005792), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: PDI-like 1-2 (TAIR:AT1G77510.1); Has 30765 Blast hits to 17459 proteins in 2902 species: Archae - 337; Bacteria - 14753; Metazoa - 5498; Fungi - 1629; Plants - 2433; Viruses - 29; Other Eukaryotes - 6086 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

7645610..7648855

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102024.4 → NP_173594.1 PDI-like 1-1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173594.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XI01

UniProtKB/TrEMBL

A0A178WAM1, A0A5S9VFG3

Conserved Domains (1) summary

TIGR01130
Location:30 → 481

ER_PDI_fam; protein disulfide isomerase, eukaryotic
NM_179365.1 → NP_849696.1 PDI-like 1-1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849696.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9VFG3, F4HZN9

Conserved Domains (5) summary

cd02981
Location:144 → 240

PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...

cd02982
Location:258 → 355

PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...

cd02995
Location:375 → 477

PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...

TIGR01130
Location:30 → 478

ER_PDI_fam; protein disulfide isomerase, eukaryotic

cl00388
Location:39 → 140

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold