DWF5 Ergosterol biosynthesis ERG4/ERG24 family [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DWF5
Official Full Name: Ergosterol biosynthesis ERG4/ERG24 family
Primary source: TAIR:AT1G50430
Locus tag: AT1G50430
See related: Araport:AT1G50430
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 7-STEROL DELTA7 REDUCTASE; 7RED; DELTA5; DWARF 5; F11F12.21; F11F12_21; LE; LEPIDA; PA; PARVA; ST7R; STEROL DELTA7 REDUCTASE
Summary: Mutants are defective in Brassinosteroid biosynthesis (delta7-sterol-C7 reduction step) and have a dwarf phenotype.
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Genomic context

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See DWF5 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 13

Sequence:: Chromosome: 1; NC_003070.9 (18681932..18685652, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both Delta(5,7)-sterol-Delta(7)-reductase and Delta(24)-sterol-Delta(24)-reductase are in addition localized to the plasma membrane, whereas Delta(7)-sterol-C(5)-desaturase was clearly detected in lipid particles
Title: Plant sterol metabolism. Δ(7)-Sterol-C5-desaturase (STE1/DWARF7), Δ(5,7)-sterol-Δ(7)-reductase (DWARF5) and Δ(24)-sterol-Δ(24)-reductase (DIMINUTO/DWARF1) show multiple subcellular localizations in Arabidopsis thaliana (Heynh) L.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001084224.1

Supported by ESTs:

NM_103926.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 7-dehydrocholesterol reductase activity	IEA Inferred from Electronic Annotation more info
enables 7-dehydrocholesterol reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brassinosteroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sterol biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within unidimensional cell growth	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Ergosterol biosynthesis ERG4/ERG24 family

NP_001077693.1

DWARF 5 (DWF5); FUNCTIONS IN: sterol delta7 reductase activity; INVOLVED IN: sterol biosynthetic process, unidimensional cell growth, brassinosteroid biosynthetic process; LOCATED IN: integral to endoplasmic reticulum membrane, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sterol reductase, conserved site (InterPro:IPR018083), Ergosterol biosynthesis ERG4/ERG24 (InterPro:IPR001171); BEST Arabidopsis thaliana protein match is: Ergosterol biosynthesis ERG4/ERG24 family (TAIR:AT3G52940.1); Has 974 Blast hits to 971 proteins in 205 species: Archae - 0; Bacteria - 51; Metazoa - 266; Fungi - 402; Plants - 150; Viruses - 3; Other Eukaryotes - 102 (source: NCBI BLink).

NP_175460.1

DWARF 5 (DWF5); FUNCTIONS IN: sterol delta7 reductase activity; INVOLVED IN: sterol biosynthetic process, unidimensional cell growth, brassinosteroid biosynthetic process; LOCATED IN: integral to endoplasmic reticulum membrane, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sterol reductase, conserved site (InterPro:IPR018083), Ergosterol biosynthesis ERG4/ERG24 (InterPro:IPR001171); BEST Arabidopsis thaliana protein match is: Ergosterol biosynthesis ERG4/ERG24 family (TAIR:AT3G52940.1); Has 989 Blast hits to 986 proteins in 209 species: Archae - 0; Bacteria - 51; Metazoa - 267; Fungi - 416; Plants - 150; Viruses - 3; Other Eukaryotes - 102 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

18681932..18685652 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_103926.5 → NP_175460.1 Ergosterol biosynthesis ERG4/ERG24 family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_175460.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38930, Q9LDU6

UniProtKB/TrEMBL

A0A178W1U5, A0A384L6G7, Q0WU95

Conserved Domains (1) summary

cl21511
Location:62 → 432

PEMT; Phospholipid methyltransferase
NM_001084224.1 → NP_001077693.1 Ergosterol biosynthesis ERG4/ERG24 family [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001077693.1

Status: REVIEWED

UniProtKB/TrEMBL

A8MS34

Conserved Domains (1) summary

cl21511
Location:62 → 431

PEMT; Phospholipid methyltransferase