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    HO3 heme oxygenase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843308, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HO3
    Official Full Name
    heme oxygenase 3
    Primary source
    TAIR:AT1G69720
    Locus tag
    AT1G69720
    See related
    Araport:AT1G69720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    heme oxygenase 3; T6C23.8; T6C23_8
    Summary
    Encodes a member (HO3) of the heme oxygenase family.
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    Genomic context

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    See HO3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (26226731..26228580)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene HVA22 homologue C Neighboring gene Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain-containing protein Neighboring gene Wall-associated kinase family protein Neighboring gene Aldolase superfamily protein Neighboring gene cytochrome c oxidase 19-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the haem oxygenase protein family in Arabidopsis thaliana reveals a diversity of functions. Gisk B, et al. Biochem J, 2010 Jan 15. PMID 19860740
    2. Multiple heme oxygenase family members contribute to the biosynthesis of the phytochrome chromophore in Arabidopsis. Emborg TJ, et al. Plant Physiol, 2006 Mar. PMID 16428602, Free PMC Article
    3. The Arabidopsis photomorphogenic mutant hy1 is deficient in phytochrome chromophore biosynthesis as a result of a mutation in a plastid heme oxygenase. Muramoto T, et al. Plant Cell, 1999 Mar. PMID 10072395, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. multiple members of the Arabidopsis HO family are important for synthesizing the bilin chromophore used to assemble photochemically active phytochrome. [HO3]
      Title: Multiple heme oxygenase family members contribute to the biosynthesis of the phytochrome chromophore in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001124102.1
    NM_001334420.1
    NM_105640.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme oxygenase (decyclizing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    heme oxygenase 3
    NP_001117574.1
    • heme oxygenase 3 (HO3); FUNCTIONS IN: heme oxygenase (decyclizing) activity, heme binding; INVOLVED IN: oxidation reduction, heme oxidation; LOCATED IN: chloroplast; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Haem oxygenase-like, multi-helical (InterPro:IPR016084), Haem oxygenase-like (InterPro:IPR016053); BEST Arabidopsis thaliana protein match is: Plant haem oxygenase (decyclizing) family protein (TAIR:AT2G26670.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_177130.1
    • heme oxygenase 3 (HO3); FUNCTIONS IN: heme oxygenase (decyclizing) activity, heme binding; INVOLVED IN: oxidation reduction, heme oxidation; LOCATED IN: chloroplast; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Haem oxygenase-like, multi-helical (InterPro:IPR016084), Haem oxygenase-like (InterPro:IPR016053), Haem oxygenase (decyclizing), plant (InterPro:IPR016951); BEST Arabidopsis thaliana protein match is: Plant haem oxygenase (decyclizing) family protein (TAIR:AT2G26670.1); Has 543 Blast hits to 543 proteins in 142 species: Archae - 0; Bacteria - 177; Metazoa - 122; Fungi - 0; Plants - 114; Viruses - 0; Other Eukaryotes - 130 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26226731..26228580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105640.4 → NP_177130.1  heme oxygenase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177130.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H531, Q9C9L4
      UniProtKB/TrEMBL
      A0A178WK98, A0A654EMU9
      Conserved Domains (1) summary
      cd19165
      Location:76 → 283
      HemeO; heme oxygenase in eukaryotes and some bacteria

    2. NM_001124102.1 → NP_001117574.1  heme oxygenase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001117574.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C9L4
      Conserved Domains (1) summary
      cd00232
      Location:76 → 222
      HemeO; Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This ...

    3. NM_001334420.1 → NP_001321799.1  heme oxygenase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H531, Q9C9L4
      UniProtKB/TrEMBL
      A0A178WK98, A0A654EMU9
      Conserved Domains (1) summary
      cd19165
      Location:76 → 283
      HemeO; heme oxygenase in eukaryotes and some bacteria
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C9L4.1

    Gene LinkOut

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