HEMB1 Aldolase superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HEMB1
Official Full Name: Aldolase superfamily protein
Primary source: TAIR:AT1G69740
Locus tag: AT1G69740
See related: Araport:AT1G69740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Summary: Encodes a putative 5-aminolevulinate dehydratase involved in chlorophyll biosynthesis.
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Genomic context

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See HEMB1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 13

Sequence:: Chromosome: 1; NC_003070.9 (26231620..26235043)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transposase-derived proteins FHY3/FAR1 interact with PHYTOCHROME-INTERACTING FACTOR1 to regulate chlorophyll biosynthesis by modulating HEMB1 during deetiolation in Arabidopsis.
Title: Transposase-derived proteins FHY3/FAR1 interact with PHYTOCHROME-INTERACTING FACTOR1 to regulate chlorophyll biosynthesis by modulating HEMB1 during deetiolation in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001084331.3

Supported by ESTs:

NM_001334421.1

Supported by ESTs:

NM_105642.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables porphobilinogen synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chlorophyll biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: Aldolase superfamily protein

NP_001077800.1

HEMB1; FUNCTIONS IN: porphobilinogen synthase activity, catalytic activity, metal ion binding; INVOLVED IN: porphyrin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Tetrapyrrole biosynthesis, porphobilinogen synthase (InterPro:IPR001731); BEST Arabidopsis thaliana protein match is: Aldolase superfamily protein (TAIR:AT1G44318.1); Has 6820 Blast hits to 6820 proteins in 2111 species: Archae - 162; Bacteria - 3714; Metazoa - 160; Fungi - 160; Plants - 86; Viruses - 0; Other Eukaryotes - 2538 (source: NCBI BLink).

NP_177132.1

HEMB1; FUNCTIONS IN: porphobilinogen synthase activity, catalytic activity, metal ion binding; INVOLVED IN: porphyrin biosynthetic process; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Tetrapyrrole biosynthesis, porphobilinogen synthase (InterPro:IPR001731); BEST Arabidopsis thaliana protein match is: Aldolase superfamily protein (TAIR:AT1G44318.1); Has 6820 Blast hits to 6820 proteins in 2111 species: Archae - 162; Bacteria - 3714; Metazoa - 160; Fungi - 160; Plants - 86; Viruses - 0; Other Eukaryotes - 2538 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

26231620..26235043

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105642.4 → NP_177132.1 Aldolase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177132.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SFH9

UniProtKB/TrEMBL

A0A178WCT0, A0A5S9WSU6

Conserved Domains (1) summary

cd04823
Location:106 → 426

ALAD_PBGS_aspartate_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...
NM_001334421.1 → NP_001320950.1 Aldolase superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SFH9

UniProtKB/TrEMBL

A0A178WCT0, A0A5S9WSU6

Conserved Domains (1) summary

cd04823
Location:106 → 426

ALAD_PBGS_aspartate_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...
NM_001084331.3 → NP_001077800.1 Aldolase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001077800.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SFH9

UniProtKB/TrEMBL

A0A178WCT0, A0A5S9WSU6

Conserved Domains (1) summary

cd04823
Location:106 → 426

ALAD_PBGS_aspartate_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...