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    NAP57 homologue of NAP57 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824882, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NAP57
    Official Full Name
    homologue of NAP57
    Primary source
    TAIR:AT3G57150
    Locus tag
    AT3G57150
    See related
    Araport:AT3G57150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCBF5; AtNAP57; CBF5; homologue of NAP57
    Summary
    Encodes a putative pseudouridine synthase (NAP57).
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    Genomic context

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    See NAP57 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (21153815..21156075, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat family protein / BTB/POZ domain-containing protein Neighboring gene sugar-dependent 1-like protein Neighboring gene ncRNA Neighboring gene cysteine-rich TM module stress tolerance protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of Arabidopsis thaliana AtNAP57--a homologue of yeast pseudouridine synthase Cbf5p. Maceluch J, et al. Acta Biochim Pol, 2001. PMID 11833778
    2. Arabidopsis retains vertebrate-type telomerase accessory proteins via a plant-specific assembly. Song J, et al. Nucleic Acids Res, 2021 Sep 20. PMID 34403479, Free PMC Article
    3. Arabidopsis CBF5 interacts with the H/ACA snoRNP assembly factor NAF1. Lermontova I, et al. Plant Mol Biol, 2007 Nov. PMID 17712600
    4. Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance. Kannan K, et al. Mol Cell Biol, 2008 Apr. PMID 18212040, Free PMC Article
    5. Mutations in SUPPRESSOR OF VARIEGATION1, a factor required for normal chloroplast translation, suppress var2-mediated leaf variegation in Arabidopsis. Yu F, et al. Plant Cell, 2008 Jul. PMID 18599582, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis retains vertebrate-type telomerase accessory proteins via a plant-specific assembly.
      Title: Arabidopsis retains vertebrate-type telomerase accessory proteins via a plant-specific assembly.
    2. AtNAP57 is a conserved component of the telomerase RNP in multicellular organisms that is required for telomere maintenance. [AtNAP57]
      Title: Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance.
    3. T66A NAP57 behaves as a dominant-negative inhibitor of telomerase. dyskerin is a conserved component of the telomerase RNP complex in higher eukaryotes that is required for maximal enzyme activity in vivo.
      Title: Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance.
    4. [CBF5] Arabidopsis CBF5 interacts with NAF1 in planta.
      Title: Arabidopsis CBF5 interacts with the H/ACA snoRNP assembly factor NAF1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115574.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables pseudouridine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables pseudouridine synthase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    homologue of NAP57
    NP_191274.1
    • homologue of NAP57 (NAP57); FUNCTIONS IN: pseudouridine synthase activity; INVOLVED IN: pseudouridine synthesis, RNA modification, RNA processing; LOCATED IN: cytosol, nucleolus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pseudouridine synthase, catalytic domain (InterPro:IPR020103), Pseudouridine synthase/archaeosine transglycosylase-like (InterPro:IPR015947), Pseudouridine synthase/archaeosine transglycosylase (InterPro:IPR002478), H/ACA ribonucleoprotein complex, subunit Cbf5 (InterPro:IPR004802), Pseudouridine synthase II, TruB, N-terminal (InterPro:IPR002501), Dyskerin-like (InterPro:IPR012960), Uncharacterised domain 2 (InterPro:IPR004521); BEST Arabidopsis thaliana protein match is: Pseudouridine synthase family protein (TAIR:AT5G14460.1); Has 114172 Blast hits to 55339 proteins in 3754 species: Archae - 551; Bacteria - 17094; Metazoa - 41477; Fungi - 11530; Plants - 5704; Viruses - 752; Other Eukaryotes - 37064 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21153815..21156075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115574.3 → NP_191274.1  homologue of NAP57 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42348, Q94AA2, Q9LD90
      UniProtKB/TrEMBL
      A0A178VJL1, A0A384LF80, A0A5S9XLR1, C0SVF3
      Conserved Domains (1) summary
      TIGR00425
      Location:47 → 372
      CBF5; rRNA pseudouridine synthase, putative
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LD90.1

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