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    CBR NADH:cytochrome B5 reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831645, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CBR
    Official Full Name
    NADH:cytochrome B5 reductase 1
    Primary source
    TAIR:AT5G17770
    Locus tag
    AT5G17770
    See related
    Araport:AT5G17770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCBR; CBR1; NADH:cytochrome B5 reductase 1; NADH:CYTOCHROME B5 REDUCTASE 1
    Summary
    Encodes NADH:cytochrome (Cyt) b5 reductase that displayed strict specificity to NADH for the reduction of a recombinant Cyt b5 (AtB5-A), whereas no Cyt b5 reduction was observed when NADPH was used as the electron donor.
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    Genomic context

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    See CBR in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (5864182..5866809, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene zinc finger (Ran-binding) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Osmotic stress-induced localisation switch of CBR1 from mitochondria to the endoplasmic reticulum triggers ATP production via β-oxidation to respond to osmotic shock. Xiao R, et al. Plant Cell Environ, 2023 Nov. PMID 37469026
    2. Cytochrome b5 Reductase 1 Triggers Serial Reactions that Lead to Iron Uptake in Plants. Oh YJ, et al. Mol Plant, 2016 Apr 4. PMID 26712506
    3. Cytochrome b5 reductase encoded by CBR1 is essential for a functional male gametophyte in Arabidopsis. Wayne LL, et al. Plant Cell, 2013 Aug. PMID 23995085, Free PMC Article
    4. A mutation in Arabidopsis cytochrome b5 reductase identified by high-throughput screening differentially affects hydroxylation and desaturation. Kumar R, et al. Plant J, 2006 Dec. PMID 17227547
    5. Biochemical Investigation of Membrane-Bound Cytochrome b5 and the Catalytic Domain of Cytochrome b5 Reductase from Arabidopsis thaliana. Iqbal T, et al. Biochemistry, 2022 May 17. PMID 35475372

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Osmotic stress-induced localisation switch of CBR1 from mitochondria to the endoplasmic reticulum triggers ATP production via beta-oxidation to respond to osmotic shock.
      Title: Osmotic stress-induced localisation switch of CBR1 from mitochondria to the endoplasmic reticulum triggers ATP production via β-oxidation to respond to osmotic shock.
    2. Biochemical Investigation of Membrane-Bound Cytochrome b5 and the Catalytic Domain of Cytochrome b5 Reductase from Arabidopsis thaliana.
      Title: Biochemical Investigation of Membrane-Bound Cytochrome b5 and the Catalytic Domain of Cytochrome b5 Reductase from Arabidopsis thaliana.
    3. CBR1 has a crucial role in increasing the levels of unsaturated fatty acids, which activate the PM H(+)-ATPase and thus reduce rhizosphere pH
      Title: Cytochrome b5 Reductase 1 Triggers Serial Reactions that Lead to Iron Uptake in Plants.
    4. These results indicate that cytochrome b5 reductase is not essential during vegetative growth but is required for correct pollen function and seed maturation.
      Title: Cytochrome b5 reductase encoded by CBR1 is essential for a functional male gametophyte in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121783.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    NADH:cytochrome B5 reductase 1
    NP_197279.1
    • NADH:cytochrome B5 reductase 1 (CBR); FUNCTIONS IN: cytochrome-b5 reductase activity; INVOLVED IN: electron transport chain; LOCATED IN: endoplasmic reticulum, plasma membrane, plant-type cell wall; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Oxidoreductase, FAD-binding domain (InterPro:IPR008333), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), NADH:cytochrome b5 reductase (CBR) (InterPro:IPR001834); BEST Arabidopsis thaliana protein match is: FAD/NAD(P)-binding oxidoreductase (TAIR:AT5G20080.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5864182..5866809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121783.5 → NP_197279.1  NADH:cytochrome B5 reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197279.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93YQ9, Q9ZNT1
      UniProtKB/TrEMBL
      A0A178US77, A0A5S9Y525
      Conserved Domains (1) summary
      cd06183
      Location:50 → 281
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZNT1.1

    Gene LinkOut

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