CHY1 beta-hydroxyisobutyryl-CoA hydrolase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CHY1
Official Full Name: beta-hydroxyisobutyryl-CoA hydrolase 1
Primary source: TAIR:AT5G65940
Locus tag: AT5G65940
See related: Araport:AT5G65940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: beta-hydroxyisobutyryl-CoA hydrolase 1; COA-THIOESTER HYDROLASE; K14B20.11; K14B20_11
Summary: hydrolyzes beta-hydroxyisobutyryl-CoA
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Genomic context

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See CHY1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 15

Sequence:: Chromosome: 5; NC_003076.8 (26376578..26379681, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest that at least a part of benzoic acid biosynthesis occurs in the peroxisomes, although the specific pathway that leads to benzoic acid and the specific biochemical role of Chy1 remain unclear.
Title: Arabidopsis Chy1 null mutants are deficient in benzoic acid-containing glucosinolates in the seeds.
CHY1 encodes an enzyme acting in valine catabolism; seedlings deficient in CHY1 are sucrose-dependent during germination, probably because accumulation of a valine catabolic intermediate blocks fatty acid beta-oxidation.
Title: chy1, an Arabidopsis mutant with impaired beta-oxidation, is defective in a peroxisomal beta-hydroxyisobutyryl-CoA hydrolase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001037078.2

Supported by ESTs:

NM_001085335.1

Supported by ESTs:

NM_001345728.1

Supported by ESTs:

NM_125991.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 3-hydroxyisobutyryl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-hydroxyisobutyryl-CoA hydrolase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid beta-oxidation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to auxin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in valine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within valine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in valine catabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: beta-hydroxyisobutyryl-CoA hydrolase 1

NP_001032155.1

beta-hydroxyisobutyryl-CoA hydrolase 1 (CHY1); CONTAINS InterPro DOMAIN/s: Crotonase, core (InterPro:IPR001753); BEST Arabidopsis thaliana protein match is: ATP-dependent caseinolytic (Clp) protease/crotonase family protein (TAIR:AT2G30660.1); Has 31717 Blast hits to 31706 proteins in 2246 species: Archae - 411; Bacteria - 21637; Metazoa - 1269; Fungi - 836; Plants - 624; Viruses - 0; Other Eukaryotes - 6940 (source: NCBI BLink).

NP_001078804.1

beta-hydroxyisobutyryl-CoA hydrolase 1 (CHY1); CONTAINS InterPro DOMAIN/s: Crotonase, core (InterPro:IPR001753); BEST Arabidopsis thaliana protein match is: ATP-dependent caseinolytic (Clp) protease/crotonase family protein (TAIR:AT2G30660.1); Has 31609 Blast hits to 31599 proteins in 2217 species: Archae - 411; Bacteria - 21537; Metazoa - 1271; Fungi - 809; Plants - 626; Viruses - 0; Other Eukaryotes - 6955 (source: NCBI BLink).

NP_201395.1

beta-hydroxyisobutyryl-CoA hydrolase 1 (CHY1); CONTAINS InterPro DOMAIN/s: Crotonase, core (InterPro:IPR001753); BEST Arabidopsis thaliana protein match is: ATP-dependent caseinolytic (Clp) protease/crotonase family protein (TAIR:AT2G30660.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

26376578..26379681 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125991.4 → NP_201395.1 beta-hydroxyisobutyryl-CoA hydrolase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_201395.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8MQ94, C0Z2V8, Q2V2U8, Q9LKJ1

UniProtKB/TrEMBL

A0A5S9YI55, A0A654GEH2

Conserved Domains (1) summary

cl23717
Location:1 → 378

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
NM_001345728.1 → NP_001330538.1 beta-hydroxyisobutyryl-CoA hydrolase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

A8MQ94, C0Z2V8, Q2V2U8, Q9LKJ1

UniProtKB/TrEMBL

A0A5S9YI55, A0A654GEH2

Conserved Domains (1) summary

cl23717
Location:1 → 378

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
NM_001085335.1 → NP_001078804.1 beta-hydroxyisobutyryl-CoA hydrolase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078804.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654GEH2

Conserved Domains (2) summary

PRK05617
Location:7 → 335

PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional

cl23717
Location:1 → 335

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
NM_001037078.2 → NP_001032155.1 beta-hydroxyisobutyryl-CoA hydrolase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001032155.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UQY3, A0A654GEH2

Conserved Domains (1) summary

cl23717
Location:1 → 325

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...