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    MAP1A methionine aminopeptidase 1A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819132, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MAP1A
    Official Full Name
    methionine aminopeptidase 1A
    Primary source
    TAIR:AT2G45240
    Locus tag
    AT2G45240
    See related
    Araport:AT2G45240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F4L23.25; methionine aminopeptidase 1A
    Summary
    Encodes a cytoplasmic MAP1 like methionine aminopeptidase which is involved in removing the N-terminal methionine from proteins. Induced mutants using RNAi technology which knocks out both MAP1 and MAP2 like genes show abnormal development.
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    Genomic context

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    See MAP1A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Sequence:
    Chromosome: 2; NC_003071.7 (18655760..18659111)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene integral membrane hemolysin-III-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cotranslational proteolysis dominates glutathione homeostasis to support proper growth and development. Frottin F, et al. Plant Cell, 2009 Oct. PMID 19855051, Free PMC Article
    2. Functional and developmental impact of cytosolic protein N-terminal methionine excision in Arabidopsis. Ross S, et al. Plant Physiol, 2005 Feb. PMID 15681659, Free PMC Article
    3. Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms. Giglione C, et al. EMBO J, 2000 Nov 1. PMID 11060042, Free PMC Article
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337118.1
    NM_130087.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables initiator methionyl aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-terminal protein amino acid modification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein processing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine aminopeptidase 1A
    NP_182049.1
    • methionine aminopeptidase 1A (MAP1A); FUNCTIONS IN: metalloexopeptidase activity, aminopeptidase activity, zinc ion binding; INVOLVED IN: protein processing, N-terminal protein amino acid modification; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, MYND-type (InterPro:IPR002893), Peptidase M24, structural domain (InterPro:IPR000994), Peptidase M24A, methionine aminopeptidase, subfamily 1 (InterPro:IPR002467), Peptidase M24, methionine aminopeptidase (InterPro:IPR001714); BEST Arabidopsis thaliana protein match is: methionine aminopeptidase 1B (TAIR:AT1G13270.1); Has 18085 Blast hits to 18064 proteins in 2832 species: Archae - 403; Bacteria - 12111; Metazoa - 396; Fungi - 241; Plants - 256; Viruses - 0; Other Eukaryotes - 4678 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18655760..18659111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130087.4 → NP_182049.1  methionine aminopeptidase 1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q548T6, Q8LAQ1, Q9SLN5
      UniProtKB/TrEMBL
      A0A178W006, A0A654F239, Q0WUD9
      Conserved Domains (1) summary
      PLN03158
      Location:4 → 398
      PLN03158; methionine aminopeptidase; Provisional

    2. NM_001337118.1 → NP_001325142.1  methionine aminopeptidase 1A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W006, A0A1P8B297
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SLN5.1

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