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    Aqr aquarius [ Mus musculus (house mouse) ]

    Gene ID: 11834, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aqrprovided by MGI
    Official Full Name
    aquariusprovided by MGI
    Primary source
    MGI:MGI:1276102
    See related
    Ensembl:ENSMUSG00000040383 AllianceGenome:MGI:1276102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0560
    Summary
    Predicted to enable 3'-5' RNA helicase activity; mRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U2-type catalytic step 2 spliceosome. Orthologous to human AQR (aquarius intron-binding spliceosomal factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.8), limb E14.5 (RPKM 15.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Aqr in Genome Data Viewer
    Location:
    2 E4; 2 57.57 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (113931642..114005788, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (114101161..114175339, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene actin, alpha, cardiac muscle 1 divergent transcript Neighboring gene predicted gene, 46757 Neighboring gene predicted gene, 54143 Neighboring gene VISTA enhancer mm182 Neighboring gene STARR-positive B cell enhancer mm9_chr2:113971248-113971549 Neighboring gene STARR-positive B cell enhancer ABC_E1593 Neighboring gene STARR-seq mESC enhancer starr_05403 Neighboring gene microRNA 7002 Neighboring gene zinc finger protein 770 Neighboring gene STARR-seq mESC enhancer starr_05404 Neighboring gene STARR-seq mESC enhancer starr_05405 Neighboring gene STARR-seq mESC enhancer starr_05406 Neighboring gene STARR-seq mESC enhancer starr_05407 Neighboring gene STARR-seq mESC enhancer starr_05408 Neighboring gene STARR-seq mESC enhancer starr_05409 Neighboring gene predicted gene, 31146

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3'-5' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of U2-type catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RNA helicase aquarius
    Names
    intron-binding protein aquarius
    intron-binding protein of 160 kDa
    NP_001277717.1
    NP_001403810.1
    NP_001403811.1
    NP_001403813.1
    NP_001403814.1
    NP_001403815.1
    NP_001403816.1
    NP_001403818.1
    NP_001403819.1
    NP_033832.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290788.2NP_001277717.1  RNA helicase aquarius isoform b

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569
      Consensus CDS
      CCDS71114.1
      UniProtKB/TrEMBL
      A2AQA7
      Related
      ENSMUSP00000099602.5, ENSMUST00000102543.5
      Conserved Domains (4) summary
      pfam13086
      Location:8051111
      AAA_11; AAA domain
      pfam13245
      Location:808880
      AAA_19; Part of AAA domain
      pfam16399
      Location:18802
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:11191308
      UvrD_C_2; UvrD-like helicase C-terminal domain
    2. NM_001416881.1NP_001403810.1  RNA helicase aquarius isoform c

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569
    3. NM_001416882.1NP_001403811.1  RNA helicase aquarius isoform d

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569
    4. NM_001416884.1NP_001403813.1  RNA helicase aquarius isoform g

      Status: VALIDATED

      Source sequence(s)
      AL844569
    5. NM_001416885.1NP_001403814.1  RNA helicase aquarius isoform h

      Status: VALIDATED

      Source sequence(s)
      AL844569
    6. NM_001416886.1NP_001403815.1  RNA helicase aquarius isoform i

      Status: VALIDATED

      Source sequence(s)
      AL844569
      Related
      ENSMUST00000129504.8
    7. NM_001416887.1NP_001403816.1  RNA helicase aquarius isoform j

      Status: VALIDATED

      Source sequence(s)
      AL844569
    8. NM_001416889.1NP_001403818.1  RNA helicase aquarius isoform e

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569
    9. NM_001416890.1NP_001403819.1  RNA helicase aquarius isoform f

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569
    10. NM_009702.4NP_033832.2  RNA helicase aquarius isoform a

      See identical proteins and their annotated locations for NP_033832.2

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569
      Consensus CDS
      CCDS16565.1
      UniProtKB/Swiss-Prot
      P97871, Q3U9N1, Q3ULE8, Q80TX8, Q8CFQ3
      Related
      ENSMUSP00000047157.7, ENSMUST00000043160.13
      Conserved Domains (4) summary
      pfam13086
      Location:8051111
      AAA_11; AAA domain
      pfam13245
      Location:808880
      AAA_19; Part of AAA domain
      pfam16399
      Location:18802
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:11191308
      UvrD_C_2; UvrD-like helicase C-terminal domain

    RNA

    1. NR_184400.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      113931642..114005788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)