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    Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 16524, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnj9provided by MGI
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 9provided by MGI
    Primary source
    MGI:MGI:108007
    See related
    Ensembl:ENSMUSG00000038026 AllianceGenome:MGI:108007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Girk3; Kir3.3; mbGIRK3; 1700085N21Rik
    Summary
    Predicted to enable PDZ domain binding activity and inward rectifier potassium channel activity. Involved in regulation of presynaptic membrane potential. Is active in parallel fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in central nervous system; eye; intestine; and male reproductive gland or organ. Orthologous to human KCNJ9 (potassium inwardly rectifying channel subfamily J member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 37.4), cerebellum adult (RPKM 26.5) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Kcnj9 in Genome Data Viewer
    Location:
    1 H3; 1 79.66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172148075..172156889, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172320508..172329322, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57554 Neighboring gene ATPase, Na+/K+ transporting, alpha 2 polypeptide Neighboring gene predicted gene, 39704 Neighboring gene STARR-positive B cell enhancer ABC_E5853 Neighboring gene STARR-positive B cell enhancer ABC_E11698 Neighboring gene immunoglobulin superfamily, member 8 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 10 Neighboring gene STARR-positive B cell enhancer ABC_E3331 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class M

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to G-protein activated inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    G protein-activated inward rectifier potassium channel 3
    Names
    GIRK-3
    inward rectifier K(+) channel Kir3.3
    inwardly rectifier K(+) channel Kir3.3
    potassium channel, inwardly rectifying subfamily J member 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360808.1NP_001347737.1  G protein-activated inward rectifier potassium channel 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC074311, AK046084, BC038600, BY128973
      Consensus CDS
      CCDS35783.1
      UniProtKB/Swiss-Prot
      P48543, Q9WUE1
      UniProtKB/TrEMBL
      Q544N3
      Related
      ENSMUSP00000141633.2, ENSMUST00000194204.2
      Conserved Domains (2) summary
      pfam01007
      Location:25164
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:171334
      IRK_C; Inward rectifier potassium channel C-terminal domain
    2. NM_008429.3NP_032455.2  G protein-activated inward rectifier potassium channel 3

      See identical proteins and their annotated locations for NP_032455.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK033970, BC038600, BY128973
      Consensus CDS
      CCDS35783.1
      UniProtKB/Swiss-Prot
      P48543, Q9WUE1
      UniProtKB/TrEMBL
      Q544N3
      Related
      ENSMUSP00000060110.3, ENSMUST00000062387.8
      Conserved Domains (2) summary
      pfam01007
      Location:25164
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:171334
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      172148075..172156889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)