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    Mrc2 mannose receptor, C type 2 [ Mus musculus (house mouse) ]

    Gene ID: 17534, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mrc2provided by MGI
    Official Full Name
    mannose receptor, C type 2provided by MGI
    Primary source
    MGI:MGI:107818
    See related
    Ensembl:ENSMUSG00000020695 AllianceGenome:MGI:107818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    uPARAP; Endo180; mKIAA0709
    Summary
    Predicted to enable carbohydrate binding activity; collagen binding activity; and signaling receptor activity. Predicted to be involved in collagen catabolic process. Predicted to be located in cell surface. Is expressed in several structures, including brain; head bone; meninges; metanephros; and respiratory system. Orthologous to human MRC2 (mannose receptor C-type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 31.6), lung adult (RPKM 31.1) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mrc2 in Genome Data Viewer
    Location:
    11 E1; 11 68.73 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105183440..105241971)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105292093..105351146)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700052K11 gene Neighboring gene STARR-positive B cell enhancer ABC_E8463 Neighboring gene tousled-like kinase 2 (Arabidopsis) Neighboring gene STARR-seq mESC enhancer starr_30905 Neighboring gene predicted gene, 53649 Neighboring gene STARR-positive B cell enhancer mm9_chr11:105209236-105209536 Neighboring gene uncharacterized LOC115487808 Neighboring gene membrane associated ring-CH-type finger 10 Neighboring gene predicted gene, 39417

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC141530

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-type mannose receptor 2
    Names
    lectin lambda
    macrophage mannose receptor 2
    novel lectin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008626.3NP_032652.3  C-type mannose receptor 2 precursor

      See identical proteins and their annotated locations for NP_032652.3

      Status: VALIDATED

      Source sequence(s)
      AL645684, BB665946, BC116642, BU053305
      Consensus CDS
      CCDS25539.1
      UniProtKB/Swiss-Prot
      A2AAB0, Q64449, Q6ZQ64, Q8C6P0
      UniProtKB/TrEMBL
      Q14AX9
      Related
      ENSMUSP00000097909.4, ENSMUST00000100335.10
      Conserved Domains (4) summary
      smart00059
      Location:179227
      FN2; Fibronectin type 2 domain
      cd00037
      Location:246360
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00034
      Location:381504
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:45160
      RICIN; Ricin-type beta-trefoil

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      105183440..105241971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532406.5XP_006532469.1  C-type mannose receptor 2 isoform X1

      UniProtKB/TrEMBL
      Q14AX9
      Conserved Domains (4) summary
      smart00059
      Location:214262
      FN2; Fibronectin type 2 domain
      cd00037
      Location:281395
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00034
      Location:416539
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:80195
      RICIN; Ricin-type beta-trefoil