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    GPR137 G protein-coupled receptor 137 [ Homo sapiens (human) ]

    Gene ID: 56834, updated on 10-Dec-2024

    Summary

    Official Symbol
    GPR137provided by HGNC
    Official Full Name
    G protein-coupled receptor 137provided by HGNC
    Primary source
    HGNC:HGNC:24300
    See related
    Ensembl:ENSG00000173264 AllianceGenome:HGNC:24300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C11orf4; GPR137A; TM7SF1L1
    Summary
    Predicted to be involved in several processes, including negative regulation of bone resorption; negative regulation of osteoclast differentiation; and positive regulation of TORC1 signaling. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 30.3), brain (RPKM 9.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GPR137 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64270531..64289500)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64260559..64279464)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64038003..64056972)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene PPP1R14B antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3471 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64015853-64016500 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64016501-64017146 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64017147-64017794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64019089-64019734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64019735-64020381 Neighboring gene phospholipase C beta 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:64038093-64038658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64042574-64043234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64043895-64044554 Neighboring gene BCL2 associated agonist of cell death Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64046081-64046582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3475 Neighboring gene KCNK4-CATSPERZ readthrough (NMD candidate) Neighboring gene potassium two pore domain channel subfamily K member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64066730-64067724 Neighboring gene catsper channel auxiliary subunit zeta

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    integral membrane protein GPR137
    Names
    transmembrane 7 superfamily member 1-like 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170880.2NP_001164351.1  integral membrane protein GPR137 isoform 2

      See identical proteins and their annotated locations for NP_001164351.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate in-frame exon in the central coding region compared to variant 1. The encoded protein (isoform 2) is longer, compared to isoform 1. Variants 2 and 8-12 all encode the same isoform (2).
      Source sequence(s)
      AJ250392, AP001453, BC033920, BU730610, BX119209
      Consensus CDS
      CCDS53656.1
      UniProtKB/Swiss-Prot
      Q96N19
      UniProtKB/TrEMBL
      Q9NQC5
      Related
      ENSP00000415698.2, ENST00000438980.7
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    2. NM_001170881.2NP_001164352.1  integral membrane protein GPR137 isoform 1

      See identical proteins and their annotated locations for NP_001164352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 6, and 7 all encode the same isoform (1).
      Source sequence(s)
      AP001453, BC035002, BI830247
      Consensus CDS
      CCDS53658.1
      UniProtKB/Swiss-Prot
      Q96N19
      Related
      ENSP00000366931.4, ENST00000377702.8
      Conserved Domains (2) summary
      cd21464
      Location:2749
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:16275
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. NM_001177358.2NP_001170829.1  integral membrane protein GPR137 isoform 5

      See identical proteins and their annotated locations for NP_001170829.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 5) includes an alternate segment and has a shorter and distinct C-terminus, compared to isoform 1. Variants 5 and 14-16 all encode the same isoform (5).
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53657.1
      UniProtKB/Swiss-Prot
      Q96N19
      Conserved Domains (2) summary
      cd21464
      Location:2749
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:16304
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. NM_001378076.1NP_001365005.1  integral membrane protein GPR137 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1 and 7, encodes isoform 1.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53658.1
      Conserved Domains (2) summary
      cd21464
      Location:2749
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:16275
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    5. NM_001378077.1NP_001365006.1  integral membrane protein GPR137 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 1 and 6, encodes isoform 1.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53658.1
      Conserved Domains (2) summary
      cd21464
      Location:2749
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:16275
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    6. NM_001378078.1NP_001365007.1  integral membrane protein GPR137 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 2 and 9-12, encodes isoform 2.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53656.1
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    7. NM_001378079.1NP_001365008.1  integral membrane protein GPR137 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 2, 8, and 10-12, encodes isoform 2.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53656.1
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    8. NM_001378080.1NP_001365009.1  integral membrane protein GPR137 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 2, 8, 9, 11, and 12, encodes isoform 2.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53656.1
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    9. NM_001378081.1NP_001365010.1  integral membrane protein GPR137 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 2, 8-10, and 12, encodes isoform 2.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53656.1
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    10. NM_001378082.1NP_001365011.1  integral membrane protein GPR137 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 2 and 8-11, encodes isoform 2.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53656.1
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    11. NM_001378083.1NP_001365012.1  integral membrane protein GPR137 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variant 3, encodes isoform 3.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS8066.1
      UniProtKB/Swiss-Prot
      B4DTG7, B7Z7M1, Q4G0Y9, Q8N4K6, Q96N19
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    12. NM_001378084.1NP_001365013.1  integral membrane protein GPR137 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 5, 15, and 16, encodes isoform 5.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53657.1
      Conserved Domains (2) summary
      cd21464
      Location:2749
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:16304
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    13. NM_001378085.1NP_001365014.1  integral membrane protein GPR137 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 5, 14, and 16, encodes isoform 5.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53657.1
      Conserved Domains (2) summary
      cd21464
      Location:2749
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:16304
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    14. NM_001378086.1NP_001365015.1  integral membrane protein GPR137 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 5, 14, and 15, encodes isoform 5.
      Source sequence(s)
      AP001453
      Consensus CDS
      CCDS53657.1
      Conserved Domains (2) summary
      cd21464
      Location:2749
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:16304
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    15. NM_001378087.1NP_001365016.1  integral membrane protein GPR137 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variant 18, encodes isoform 6.
      Source sequence(s)
      AP001453
    16. NM_001378088.1NP_001365017.1  integral membrane protein GPR137 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variant 17, encodes isoform 6.
      Source sequence(s)
      AP001453
    17. NM_001378089.1NP_001365018.1  integral membrane protein GPR137 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AP001453
      Conserved Domains (2) summary
      cd21464
      Location:2749
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:16273
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    18. NM_020155.4NP_064540.3  integral membrane protein GPR137 isoform 3

      See identical proteins and their annotated locations for NP_064540.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is longer than isoform 1. Variants 3 and 13 both encode the same isoform (3).
      Source sequence(s)
      AJ250392, AK056094, AP001453, BU730610, BX119209
      Consensus CDS
      CCDS8066.1
      UniProtKB/Swiss-Prot
      B4DTG7, B7Z7M1, Q4G0Y9, Q8N4K6, Q96N19
      Related
      ENSP00000321698.3, ENST00000313074.7
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. NR_165394.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001453
    2. NR_165395.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001453
    3. NR_165396.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001453
    4. NR_165397.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001453

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      64270531..64289500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427264.1XP_047283220.1  integral membrane protein GPR137 isoform X5

      UniProtKB/TrEMBL
      F5H234
    2. XM_011545168.3XP_011543470.1  integral membrane protein GPR137 isoform X1

      See identical proteins and their annotated locations for XP_011543470.1

    3. XM_017018016.2XP_016873505.1  integral membrane protein GPR137 isoform X3

    4. XM_047427263.1XP_047283219.1  integral membrane protein GPR137 isoform X4

    5. XM_047427265.1XP_047283221.1  integral membrane protein GPR137 isoform X6

      UniProtKB/TrEMBL
      F5GXI8
    6. XM_011545169.2XP_011543471.1  integral membrane protein GPR137 isoform X2

      See identical proteins and their annotated locations for XP_011543471.1

      UniProtKB/Swiss-Prot
      B4DTG7, B7Z7M1, Q4G0Y9, Q8N4K6, Q96N19
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    7. XM_005274102.3XP_005274159.1  integral membrane protein GPR137 isoform X2

      See identical proteins and their annotated locations for XP_005274159.1

      UniProtKB/Swiss-Prot
      B4DTG7, B7Z7M1, Q4G0Y9, Q8N4K6, Q96N19
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    8. XM_005274104.3XP_005274161.1  integral membrane protein GPR137 isoform X2

      See identical proteins and their annotated locations for XP_005274161.1

      UniProtKB/Swiss-Prot
      B4DTG7, B7Z7M1, Q4G0Y9, Q8N4K6, Q96N19
      Related
      ENSP00000411827.2, ENST00000411458.5
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    9. XM_005274100.3XP_005274157.1  integral membrane protein GPR137 isoform X2

      See identical proteins and their annotated locations for XP_005274157.1

      UniProtKB/Swiss-Prot
      B4DTG7, B7Z7M1, Q4G0Y9, Q8N4K6, Q96N19
      Conserved Domains (1) summary
      cd21474
      Location:16325
      7tm_GPR137A; Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      64260559..64279464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369376.1XP_054225351.1  integral membrane protein GPR137 isoform X5

      UniProtKB/TrEMBL
      F5H234
    2. XM_054369369.1XP_054225344.1  integral membrane protein GPR137 isoform X1

    3. XM_054369374.1XP_054225349.1  integral membrane protein GPR137 isoform X3

    4. XM_054369377.1XP_054225352.1  integral membrane protein GPR137 isoform X6

      UniProtKB/TrEMBL
      F5GXI8
    5. XM_054369372.1XP_054225347.1  integral membrane protein GPR137 isoform X2

      UniProtKB/Swiss-Prot
      B4DTG7, B7Z7M1, Q4G0Y9, Q8N4K6, Q96N19
    6. XM_054369375.1XP_054225350.1  integral membrane protein GPR137 isoform X4

    7. XM_054369371.1XP_054225346.1  integral membrane protein GPR137 isoform X2

      UniProtKB/Swiss-Prot
      B4DTG7, B7Z7M1, Q4G0Y9, Q8N4K6, Q96N19
    8. XM_054369370.1XP_054225345.1  integral membrane protein GPR137 isoform X2

      UniProtKB/Swiss-Prot
      B4DTG7, B7Z7M1, Q4G0Y9, Q8N4K6, Q96N19
    9. XM_054369373.1XP_054225348.1  integral membrane protein GPR137 isoform X2

      UniProtKB/Swiss-Prot
      B4DTG7, B7Z7M1, Q4G0Y9, Q8N4K6, Q96N19

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001170726.1: Suppressed sequence

      Description
      NM_001170726.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.