PLCH1 phospholipase C eta 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLCH1provided by HGNC
Official Full Name: phospholipase C eta 1provided by HGNC
Primary source: HGNC:HGNC:29185
See related: Ensembl:ENSG00000114805 MIM:612835; AllianceGenome:HGNC:29185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HPE14; PLCL3; PLC-L3; PLC eta 1
Summary: PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
Expression: Biased expression in testis (RPKM 4.0), thyroid (RPKM 1.7) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q25.31

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (155450934..155745071, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (158220392..158518944, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (155197670..155462860, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in phospholipase C eta-1 (PLCH1) are associated with holoprosencephaly.
Title: Mutations in phospholipase C eta-1 (PLCH1) are associated with holoprosencephaly.
High fertilization (56.06%) and pregnancy (41.7%) rates accomplished in this study following ICSI-AOA indicated that expression profiles of PLCzeta, PAWP, and TR-KIT were low in globozoospermic individuals
Title: Expression profile of PLCζ, PAWP, and TR-KIT in association with fertilization potential, embryo development, and pregnancy outcomes in globozoospermic candidates for intra-cytoplasmic sperm injection and artificial oocyte activation.
A molecular model of the PLCeta2 EF-hand domain, constructed based upon the structure of calmodulin, suggested both EF-loops may participate in Ca(2+) -binding.
Title: A canonical EF-loop directs Ca(2+) -sensitivity in phospholipase C-η2.
The PLCH1 rs181696 single-nucleotide polymorphism was strongly associated with an increased risk of squamous cell carcinoma.
Title: Association between polymorphisms in COMT, PLCH1, and CYP17A1, and non-small-cell lung cancer risk in Chinese nonsmokers.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
The identification of a novel PLC isoform in the brains of human and mouse, named PLC-eta, which contains the conserved pleckstrin homology domain, X and Y domains for catalytic activity and the C2 domain.
Title: Molecular cloning and characterization of a novel phospholipase C, PLC-eta.
molecular cloning of PLC-eta1 and PLC-eta2
Title: Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Holoprosencephaly 14 MedGen: C5676994 OMIM: 619895 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells	PubMed
Tat	tat	Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-77479 (e-PCR)
- UniSTS:65307

D3S1526 (e-PCR)
- UniSTS:62752

SHGC-53318 (e-PCR)
- UniSTS:51032

RH103840 (e-PCR)
- UniSTS:98165

PLCL3_9298 (e-PCR)
- UniSTS:468604

D3S2933E (e-PCR)
- UniSTS:150917

SHGC-146493 (e-PCR)
- UniSTS:175251

D3S3509 (e-PCR)
- UniSTS:47276

STS-H67845 (e-PCR)
- UniSTS:64190

SHGC-143594 (e-PCR)
- UniSTS:171971

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

Names: PLC-eta-1; phosphoinositide phospholipase C-eta-1; phospholipase C-eta1a; phospholipase C-eta1b; phospholipase C-like 3; phospholipase C-like protein 3

NP_001124432.1

EC 3.1.4.11

NP_001124433.1

EC 3.1.4.11

NP_001336179.1

EC 3.1.4.11

NP_001336180.1

EC 3.1.4.11

NP_001336181.1

EC 3.1.4.11

NP_055811.2

EC 3.1.4.11

XP_005247295.1

EC 3.1.4.11

XP_005247296.1

EC 3.1.4.11

XP_011510862.1

EC 3.1.4.11

XP_011510863.1

EC 3.1.4.11

XP_011510864.1

EC 3.1.4.11

XP_011510867.1

EC 3.1.4.11

XP_011510868.1

EC 3.1.4.11

XP_016861412.1

EC 3.1.4.11

XP_016861414.1

EC 3.1.4.11

XP_016861415.1

EC 3.1.4.11

XP_016861416.1

EC 3.1.4.11

XP_047303701.1

EC 3.1.4.11

XP_047303702.1

EC 3.1.4.11

XP_047303703.1

EC 3.1.4.11

XP_054201713.1

EC 3.1.4.11

XP_054201714.1

EC 3.1.4.11

XP_054201715.1

EC 3.1.4.11

XP_054201716.1

EC 3.1.4.11

XP_054201717.1

EC 3.1.4.11

XP_054201718.1

EC 3.1.4.11

XP_054201719.1

EC 3.1.4.11

XP_054201720.1

EC 3.1.4.11

XP_054201721.1

EC 3.1.4.11

XP_054201722.1

EC 3.1.4.11

XP_054201723.1

EC 3.1.4.11

XP_054201724.1

EC 3.1.4.11

XP_054201725.1

EC 3.1.4.11

XP_054201726.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130960.2 → NP_001124432.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform a

See identical proteins and their annotated locations for NP_001124432.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC012022, AC132006, AK096620, AY691171, BC113950, DA206803

Consensus CDS

CCDS46939.1

UniProtKB/Swiss-Prot

Q29RV9, Q4KWH8, Q4KWH9, Q68CN0, Q86XK4, Q9H9U2, Q9UPT3

Related

ENSP00000345988.7, ENST00000340059.11

Conserved Domains (8) summary

cd00275
Location:731 → 855

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08632
Location:298 → 701

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

PLN02228
Location:227 → 872

PLN02228; Phosphoinositide phospholipase C

cd00051
Location:146 → 212

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09279
Location:227 → 298

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:147 → 208

EF-hand_7; EF-hand domain pair

cl00292
Location:441 → 542

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

cl17171
Location:22 → 128

PH-like; Pleckstrin homology-like domain
NM_001130961.2 → NP_001124433.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform c

See identical proteins and their annotated locations for NP_001124433.1

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variant 4, encodes isoform c.

Source sequence(s)

AC012022, AC132006, AK096620, AY691170, BC113950, DA206803

Consensus CDS

CCDS46940.1

UniProtKB/Swiss-Prot

Q4KWH8

Related

ENSP00000402759.2, ENST00000447496.6

Conserved Domains (4) summary

cd08632
Location:298 → 701

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

cd16220
Location:146 → 286

EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)

cl17171
Location:22 → 128

PH-like; Pleckstrin homology-like domain

cl27705
Location:273 → 841

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
NM_001349250.2 → NP_001336179.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (4), as well as variant 3, encodes isoform c.

Source sequence(s)

AC012022, AC132006

Consensus CDS

CCDS46940.1

Related

ENSP00000419100.1, ENST00000494598.5

Conserved Domains (4) summary

cd08632
Location:298 → 701

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

cd16220
Location:146 → 286

EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)

cl17171
Location:22 → 128

PH-like; Pleckstrin homology-like domain

cl27705
Location:273 → 841

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
NM_001349251.2 → NP_001336180.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (5) encodes isoform d.

Source sequence(s)

AC012022, AC104472, AC132006

Conserved Domains (4) summary

cd08632
Location:310 → 713

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

cd16220
Location:158 → 298

EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)

cl17171
Location:34 → 140

PH-like; Pleckstrin homology-like domain

cl27705
Location:285 → 853

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
NM_001349252.2 → NP_001336181.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (6) encodes isoform e.

Source sequence(s)

AC012022, AC104472, AC132006

Conserved Domains (4) summary

cd08632
Location:310 → 713

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

cd16220
Location:158 → 298

EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)

cl17171
Location:34 → 140

PH-like; Pleckstrin homology-like domain

cl27705
Location:285 → 853

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
NM_014996.4 → NP_055811.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes isoform b.

Source sequence(s)

AC012022, AC104472, AC132006

Consensus CDS

CCDS33881.2

UniProtKB/TrEMBL

A0A2U3TZV8

Related

ENSP00000417502.2, ENST00000460012.7

Conserved Domains (4) summary

cd08632
Location:310 → 713

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

cd16220
Location:158 → 298

EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)

cl17171
Location:34 → 140

PH-like; Pleckstrin homology-like domain

cl27705
Location:285 → 853

PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

155450934..155745071 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017005927.2 → XP_016861416.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9
XM_047447747.1 → XP_047303703.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8
XM_047447746.1 → XP_047303702.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7
XM_047447745.1 → XP_047303701.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4
XM_017005925.2 → XP_016861414.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3
XM_017005923.2 → XP_016861412.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2
XM_005247238.2 → XP_005247295.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

See identical proteins and their annotated locations for XP_005247295.1

Conserved Domains (8) summary

cd00275
Location:743 → 867

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08632
Location:310 → 713

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

PLN02228
Location:239 → 884

PLN02228; Phosphoinositide phospholipase C

cd00051
Location:158 → 224

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09279
Location:239 → 310

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:159 → 220

EF-hand_7; EF-hand domain pair

cl00292
Location:453 → 554

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

cl17171
Location:34 → 140

PH-like; Pleckstrin homology-like domain
XM_011512562.4 → XP_011510864.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

See identical proteins and their annotated locations for XP_011510864.1

Conserved Domains (8) summary

cd00275
Location:743 → 867

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08632
Location:310 → 713

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

PLN02228
Location:239 → 884

PLN02228; Phosphoinositide phospholipase C

cd00051
Location:158 → 224

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09279
Location:239 → 310

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:159 → 220

EF-hand_7; EF-hand domain pair

cl00292
Location:453 → 554

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

cl17171
Location:34 → 140

PH-like; Pleckstrin homology-like domain
XM_011512560.4 → XP_011510862.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

See identical proteins and their annotated locations for XP_011510862.1

Conserved Domains (8) summary

cd00275
Location:743 → 867

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08632
Location:310 → 713

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

PLN02228
Location:239 → 884

PLN02228; Phosphoinositide phospholipase C

cd00051
Location:158 → 224

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09279
Location:239 → 310

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:159 → 220

EF-hand_7; EF-hand domain pair

cl00292
Location:453 → 554

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

cl17171
Location:34 → 140

PH-like; Pleckstrin homology-like domain
XM_011512561.3 → XP_011510863.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

See identical proteins and their annotated locations for XP_011510863.1

Conserved Domains (8) summary

cd00275
Location:743 → 867

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08632
Location:310 → 713

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

PLN02228
Location:239 → 884

PLN02228; Phosphoinositide phospholipase C

cd00051
Location:158 → 224

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09279
Location:239 → 310

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:159 → 220

EF-hand_7; EF-hand domain pair

cl00292
Location:453 → 554

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

cl17171
Location:34 → 140

PH-like; Pleckstrin homology-like domain
XM_005247239.2 → XP_005247296.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

Conserved Domains (7) summary

cd00275
Location:731 → 855

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08632
Location:298 → 701

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

cd00051
Location:146 → 212

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09279
Location:227 → 298

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:147 → 208

EF-hand_7; EF-hand domain pair

cl00292
Location:441 → 542

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

cl17171
Location:22 → 128

PH-like; Pleckstrin homology-like domain
XM_011512565.3 → XP_011510867.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

See identical proteins and their annotated locations for XP_011510867.1

Conserved Domains (8) summary

cd00275
Location:713 → 837

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08632
Location:280 → 683

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

PLN02228
Location:209 → 854

PLN02228; Phosphoinositide phospholipase C

cd00051
Location:128 → 194

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09279
Location:209 → 280

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:129 → 190

EF-hand_7; EF-hand domain pair

cl00292
Location:423 → 524

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

cl17171
Location:4 → 110

PH-like; Pleckstrin homology-like domain
XM_011512566.3 → XP_011510868.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

See identical proteins and their annotated locations for XP_011510868.1

Conserved Domains (8) summary

cd00275
Location:713 → 837

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08632
Location:280 → 683

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

PLN02228
Location:209 → 854

PLN02228; Phosphoinositide phospholipase C

cd00051
Location:128 → 194

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09279
Location:209 → 280

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:129 → 190

EF-hand_7; EF-hand domain pair

cl00292
Location:423 → 524

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

cl17171
Location:4 → 110

PH-like; Pleckstrin homology-like domain
XM_017005926.1 → XP_016861415.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

Conserved Domains (8) summary

cd00275
Location:713 → 837

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08632
Location:280 → 683

PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1

PLN02228
Location:209 → 854

PLN02228; Phosphoinositide phospholipase C

cd00051
Location:128 → 194

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam09279
Location:209 → 280

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:129 → 190

EF-hand_7; EF-hand domain pair

cl00292
Location:423 → 524

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

cl17171
Location:4 → 110

PH-like; Pleckstrin homology-like domain

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

158220392..158518944 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054345751.1 → XP_054201726.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9
XM_054345750.1 → XP_054201725.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8
XM_054345749.1 → XP_054201724.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7
XM_054345744.1 → XP_054201719.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4
XM_054345743.1 → XP_054201718.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3
XM_054345742.1 → XP_054201717.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2
XM_054345738.1 → XP_054201713.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1
XM_054345741.1 → XP_054201716.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1
XM_054345739.1 → XP_054201714.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1
XM_054345740.1 → XP_054201715.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1
XM_054345748.1 → XP_054201723.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6
XM_054345746.1 → XP_054201721.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5
XM_054345747.1 → XP_054201722.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5
XM_054345745.1 → XP_054201720.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5