ITGA11 integrin subunit alpha 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ITGA11provided by HGNC
Official Full Name: integrin subunit alpha 11provided by HGNC
Primary source: HGNC:HGNC:6136
See related: Ensembl:ENSG00000137809 MIM:604789; AllianceGenome:HGNC:6136
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HsT18964
Summary: This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
Expression: Biased expression in endometrium (RPKM 12.1), urinary bladder (RPKM 2.7) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q23

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (68296532..68432163, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (66115251..66255043, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (68588870..68724502, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.
Title: PDGFRα(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.
Osteosarcoma Cells Secrete CXCL14 That Activates Integrin alpha11beta1 on Fibroblasts to Form a Lung Metastatic Niche.
Title: Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche.
Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin alpha11 expression.
Title: Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression.
Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway.
Title: Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway.
Long noncoding RNA FEZF1AS1 facilitates nonsmall cell lung cancer progression via the ITGA11/miR516b5p axis.
Title: Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis.
p75NTR optimizes the osteogenic potential of human periodontal ligament stem cells by up-regulating alpha1 integrin expression.
Title: p75NTR optimizes the osteogenic potential of human periodontal ligament stem cells by up-regulating α1 integrin expression.
Integrin alpha11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation.
Title: Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation.
integrin alpha11 pro-invasive activity relies on its ability to interact with PDGFRbeta in a ligand-dependent manner and to promote its downstream JNK activation, leading to the production of tenascin C, a pro-invasive matricellular protein.
Title: Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression.
this study presents ITGA11 as an interesting stromal therapeutic target that plays a crucial role in the regulation of the differentiation of Pancreatic stellate cells into cancer-associated fibroblasts and paracrine effects.
Title: Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer.
Data show that integrin alpha-11 (integrin alpha11) is a physiologically important receptor for Osteolectin, mediating its effect on osteogenesis.
Title: Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-147691 (e-PCR)
- UniSTS:172859

SHGC-57393 (e-PCR)
- UniSTS:20284

RH122933 (e-PCR)
- UniSTS:135230

SHGC-142055 (e-PCR)
- UniSTS:182867

D15S983 (e-PCR), detects polymorphism
- UniSTS:68231

SHGC-85354 (e-PCR)
- UniSTS:104883

RH102890 (e-PCR)
- UniSTS:97224

STS-H15811 (e-PCR)
- UniSTS:31741

SHGC-150911 (e-PCR)
- UniSTS:173565

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables collagen binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables collagen binding involved in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
enables collagen receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	TAS Traceable Author Statement more info	PubMed
involved_in osteoblast differentiation	HDA more info	PubMed
involved_in substrate-dependent cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	HDA more info	PubMed
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha11-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	HDA more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: integrin alpha-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_046911.1 RefSeqGene

Range

4998..140629

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001004439.2 → NP_001004439.1 integrin alpha-11 precursor

See identical proteins and their annotated locations for NP_001004439.1

Status: REVIEWED

Source sequence(s)

AC021553, AC100825, AF109681, AF137378, AK095863, AL359064, BX496541, CN358985

Consensus CDS

CCDS45291.1

UniProtKB/Swiss-Prot

J3KQM2, Q8WYI8, Q9UKQ1, Q9UKX5

UniProtKB/TrEMBL

A8K8T0

Related

ENSP00000327290.7, ENST00000315757.9

Conserved Domains (3) summary

smart00191
Location:538 → 592

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:163 → 341

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:635 → 1034

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

68296532..68432163 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011521363.3 → XP_011519665.1 integrin alpha-11 isoform X1

UniProtKB/TrEMBL

A8K8T0

Conserved Domains (3) summary

smart00191
Location:469 → 523

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:94 → 272

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:566 → 965

Integrin_alpha2; Integrin alpha
XM_005254228.4 → XP_005254285.1 integrin alpha-11 isoform X2

UniProtKB/TrEMBL

A8K8T0

Conserved Domains (3) summary

smart00191
Location:436 → 490

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:61 → 239

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:533 → 932

Integrin_alpha2; Integrin alpha

Alternate T2T-CHM13v2.0

Genomic

NC_060939.1 Alternate T2T-CHM13v2.0

Range

66115251..66255043 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_012211.3: Suppressed sequence

Description

NM_012211.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.