U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gyg1 glycogenin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81675, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gyg1provided by RGD
    Official Full Name
    glycogenin 1provided by RGD
    Primary source
    RGD:621785
    See related
    EnsemblRapid:ENSRNOG00000011146 AllianceGenome:RGD:621785
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gyg
    Summary
    Enables D-glucose binding activity and glycogenin glucosyltransferase activity. Involved in glycogen biosynthetic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease XV. Orthologous to human GYG1 (glycogenin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1259.3), Heart (RPKM 551.6) and 7 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gyg1 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (104540927..104583038, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (102611888..102653916, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104916734..104958219, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485607 Neighboring gene helicase-like transcription factor Neighboring gene eukaryotic translation initiation factor 4 gamma 1, pseudogene 1 Neighboring gene carboxypeptidase A3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. No limiting role for glycogenin in determining maximal attainable glycogen levels in rat skeletal muscle. Hansen BF, et al. Am J Physiol Endocrinol Metab, 2000 Mar. PMID 10710493
    2. Molecular cloning and developmental expression of rat glycogenin in cardiac tissue. Pak BJ, et al. Mol Cell Biochem, 1999 Apr. PMID 10391131
    3. Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis. Bilyard MK, et al. Nature, 2018 Nov. PMID 30356213
    4. Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis. Chaikuad A, et al. Proc Natl Acad Sci U S A, 2011 Dec 27. PMID 22160680, Free PMC Article
    5. Glycogenin-1 deficiency and inactivated priming of glycogen synthesis. Moslemi AR, et al. N Engl J Med, 2010 Apr 1. PMID 20357282

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glucose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycogenin glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycogenin glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycogenin glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycogenin glucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glycogenin-1
    Names
    GN-1
    GN1
    NP_112305.1
    XP_017446621.1
    XP_038959150.1
    XP_063138695.1
    XP_063138696.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031043.2 → NP_112305.1  glycogenin-1

      See identical proteins and their annotated locations for NP_112305.1

      Status: PROVISIONAL

      Source sequence(s)
      AF021343
      UniProtKB/Swiss-Prot
      A6IHC8, O08730
      UniProtKB/TrEMBL
      F8WFR6
      Related
      ENSRNOP00000014837.7, ENSRNOT00000014837.8
      Conserved Domains (2) summary
      cd02537
      Location:4 → 254
      GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
      COG1442
      Location:9 → 221
      RfaJ; Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      104540927..104583038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591132.3 → XP_017446621.1  glycogenin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXP1, F8WFR6
      Related
      ENSRNOP00000078602.2, ENSRNOT00000113908.2

    2. XM_063282626.1 → XP_063138696.1  glycogenin-1 isoform X3

    3. XM_063282625.1 → XP_063138695.1  glycogenin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLA5
      Related
      ENSRNOP00000070350.3, ENSRNOT00000080699.3

    4. XM_039103222.2 → XP_038959150.1  glycogenin-1 isoform X4

      Conserved Domains (1) summary
      cl11394
      Location:1 → 96
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RNA

    1. XR_010063663.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08730.4 GenPept UniProtKB/Swiss-Prot:O08730

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous