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    Tnik TRAF2 and NCK interacting kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294917, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tnikprovided by RGD
    Official Full Name
    TRAF2 and NCK interacting kinaseprovided by RGD
    Primary source
    RGD:1561817
    See related
    EnsemblRapid:ENSRNOG00000012422 AllianceGenome:RGD:1561817
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561817
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of dendrite morphogenesis. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 138.2), Lung (RPKM 92.5) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tnik in Genome Data Viewer
    Location:
    2q24
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (113112937..113511341)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (111184352..111587993)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (113984599..114391805)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100791 Neighboring gene uncharacterized LOC120100792 Neighboring gene uncharacterized LOC134485608 Neighboring gene uncharacterized LOC134485609 Neighboring gene solute carrier family 2 member 2 Neighboring gene eukaryotic translation initiation factor 5A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TRAF2 and NCK-interacting protein kinase
    NP_001099892.1
    XP_008759119.2
    XP_017446219.1
    XP_017446220.1
    XP_017446221.1
    XP_063137616.1
    XP_063137617.1
    XP_063137618.1
    XP_063137619.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106422.1NP_001099892.1  TRAF2 and NCK-interacting protein kinase

      See identical proteins and their annotated locations for NP_001099892.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473961
      UniProtKB/TrEMBL
      A0A8I5ZV95, A6IHI7
      Conserved Domains (3) summary
      smart00036
      Location:10341326
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      113112937..113511341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281546.1XP_063137616.1  TRAF2 and NCK-interacting protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZV95
    2. XM_017590730.3XP_017446219.1  TRAF2 and NCK-interacting protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A0G2K490, A0A8I5ZV95
      Related
      ENSRNOP00000072950.1, ENSRNOT00000086399.3
    3. XM_017590731.3XP_017446220.1  TRAF2 and NCK-interacting protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZV95, A0A8I6GLD8, A6IHI6
      Related
      ENSRNOP00000095929.1, ENSRNOT00000115354.2
      Conserved Domains (3) summary
      smart00036
      Location:10341332
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
    4. XM_063281547.1XP_063137617.1  TRAF2 and NCK-interacting protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8I6GFX7
    5. XM_017590732.3XP_017446221.1  TRAF2 and NCK-interacting protein kinase isoform X5

      UniProtKB/TrEMBL
      A0A8I6GFX7
    6. XM_063281548.1XP_063137618.1  TRAF2 and NCK-interacting protein kinase isoform X6

      UniProtKB/TrEMBL
      A0A8I6GFX7
    7. XM_008760897.4XP_008759119.2  TRAF2 and NCK-interacting protein kinase isoform X7

      UniProtKB/TrEMBL
      A0A8I6GFX7
      Related
      ENSRNOP00000080133.2, ENSRNOT00000106609.2
    8. XM_063281549.1XP_063137619.1  TRAF2 and NCK-interacting protein kinase isoform X8

      UniProtKB/TrEMBL
      A0A8I6GFX7