Fnbp1 formin binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Fnbp1provided by RGD
Full Name: formin binding protein 1provided by RGD
Primary source: RGD:621350
See related: EnsemblRapid:ENSRNOG00000008258 AllianceGenome:RGD:621350
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Involved in nervous system development. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Orthologous to human FNBP1 (formin binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 85.2), Thymus (RPKM 52.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (34706814..34826770, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (14309067..14424378, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (9865657..9936333, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

F-BAR protein Rapostlin, whose activity is regulated by Rnd2, plays a key role in spine formation through the regulation of membrane dynamics.
Title: The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons.
Data show that rapostlin is the first effector of Rnd2, regulating neurite branch formation.
Title: Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching.
Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons
Title: In vivo function of Rnd2 in the development of neocortical pyramidal neurons.
functionally different splicing variants of Rapostlin have different responses to Rnd2 in association with N-WASP.
Title: Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048475 (e-PCR)
- UniSTS:144925

RH142088 (e-PCR)
- UniSTS:224078

BE105446 (e-PCR)
- UniSTS:245844

BF399073 (e-PCR)
- UniSTS:247508

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: formin-binding protein 1

Names: formin-binding protein 1-like; formin-binding protein 17; rapostlin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393677.1 → NP_001380606.1 formin-binding protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q75UE2, Q75UE3, Q75UE4, Q75UE5, Q75UE6, Q8R511

UniProtKB/TrEMBL

Z4YNH5

Related

ENSRNOP00000092158.2, ENSRNOT00000110957.2

Conserved Domains (3) summary

cd07676
Location:5 → 257

F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17

cd11629
Location:406 → 482

HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17

cd12071
Location:552 → 608

SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17
NM_001393678.1 → NP_001380607.1 formin-binding protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

Z4YNH5

Related

ENSRNOP00000049838.6, ENSRNOT00000042798.8

Conserved Domains (3) summary

cd07676
Location:5 → 257

F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17

cd11629
Location:401 → 477

HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17

cl17036
Location:547 → 603

SH3; Src Homology 3 domain superfamily
NM_001393679.1 → NP_001380608.1 formin-binding protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A8B9

Conserved Domains (3) summary

cl00087
Location:377 → 453

HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

cl12013
Location:5 → 257

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl17036
Location:523 → 579

SH3; Src Homology 3 domain superfamily
NM_001393680.1 → NP_001380609.1 formin-binding protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A8B9

Conserved Domains (3) summary

cl00087
Location:372 → 448

HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

cl12013
Location:5 → 257

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl17036
Location:518 → 574

SH3; Src Homology 3 domain superfamily
NM_001393681.1 → NP_001380610.1 formin-binding protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A8B9

Conserved Domains (3) summary

cl00087
Location:345 → 421

HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

cl12013
Location:5 → 257

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl17036
Location:491 → 547

SH3; Src Homology 3 domain superfamily
NM_001393682.1 → NP_001380611.1 formin-binding protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A8B9

Conserved Domains (3) summary

cl00087
Location:340 → 416

HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

cl12013
Location:5 → 257

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl17036
Location:486 → 542

SH3; Src Homology 3 domain superfamily
NM_138914.2 → NP_620269.1 formin-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_620269.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

Z4YNH5

Conserved Domains (3) summary

cd07676
Location:5 → 257

F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17

cd11629
Location:406 → 482

HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17

cd12071
Location:552 → 608

SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17