Ivns1abp influenza virus NS1A binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ivns1abpprovided by RGD
Official Full Name: influenza virus NS1A binding proteinprovided by RGD
Primary source: RGD:1306290
See related: EnsemblRapid:ENSRNOG00000002618 AllianceGenome:RGD:1306290
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to virus. Predicted to act upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Predicted to be located in cytosol and nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 70. Orthologous to human IVNS1ABP (influenza virus NS1A binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1490.3), Heart (RPKM 837.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (65977069..65996685)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (63427040..63446701)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (68702970..68722472)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143231 (e-PCR)
- UniSTS:232478

D13Rat181 (e-PCR), detects polymorphism
- UniSTS:226556

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA splicing	ISO Inferred from Sequence Orthology more info
acts_upstream_of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: influenza virus NS1A-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401342.1 → NP_001388271.1 influenza virus NS1A-binding protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A0G2K427, A6ICS0

Related

ENSRNOP00000003558.7, ENSRNOT00000003558.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

65977069..65996685

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249989.5 → XP_006250051.1 influenza virus NS1A-binding protein isoform X2

See identical proteins and their annotated locations for XP_006250051.1

UniProtKB/TrEMBL

A6ICS2, D4A0T2

Conserved Domains (2) summary

cd18306
Location:14 → 137

BTB_POZ_NS1BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP)

cd18502
Location:129 → 221

BACK_NS1BP_IVNS1ABP; BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP)
XM_039090454.1 → XP_038946382.1 influenza virus NS1A-binding protein isoform X1

Related

ENSRNOP00000071484.2, ENSRNOT00000083301.3

Conserved Domains (3) summary

smart00612
Location:151 → 197

Kelch; Kelch domain

PHA03098
Location:199 → 420

PHA03098; kelch-like protein; Provisional

sd00038
Location:235 → 280

Kelch; KELCH repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001047085.1: Suppressed sequence

Description

NM_001047085.1: This RefSeq was removed because currently there is insufficient support for the transcript.