Ctdsp1 CTD small phosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctdsp1provided by RGD
Official Full Name: CTD small phosphatase 1provided by RGD
Primary source: RGD:1305629
See related: EnsemblRapid:ENSRNOG00000015295 AllianceGenome:RGD:1305629
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in protein dephosphorylation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell differentiation; and negative regulation of protein phosphorylation. Predicted to be located in nucleoplasm. Orthologous to human CTDSP1 (CTD small phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 328.7), Lung (RPKM 263.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (83422755..83428411)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (75973694..75979298)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (81672613..81677979)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	ISO Inferred from Sequence Orthology more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Names: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

NP_001121551.1

EC 3.1.3.16

XP_006245298.1

EC 3.1.3.16

XP_038939804.1

EC 3.1.3.16

XP_063123456.1

EC 3.1.3.16

XP_063123457.1

EC 3.1.3.16

XP_063123459.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128079.1 → NP_001121551.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

See identical proteins and their annotated locations for NP_001121551.1

Status: PROVISIONAL

Source sequence(s)

BC161976

UniProtKB/TrEMBL

A0A8I6ACZ1, B1WC24, F7F6Y7

Related

ENSRNOP00000020646.3, ENSRNOT00000020646.8

Conserved Domains (1) summary

TIGR02251
Location:90 → 249

HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

83422755..83428411

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267389.1 → XP_063123459.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X4
XM_063267386.1 → XP_063123456.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X1
XM_039083876.2 → XP_038939804.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X5

UniProtKB/TrEMBL

A0A8I6ACZ1

Conserved Domains (1) summary

TIGR02251
Location:71 → 214

HIF-SF_euk; Dullard-like phosphatase domain
XM_063267387.1 → XP_063123457.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X2
XM_006245236.5 → XP_006245298.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZS34, A0A8I6ACZ1

Related

ENSRNOP00000081485.1, ENSRNOT00000102796.2

Conserved Domains (2) summary

COG5190
Location:79 → 254

FCP1; TFIIF-interacting CTD phosphatase, includes NLI-interacting factor [Transcription]

TIGR02251
Location:90 → 249

HIF-SF_euk; Dullard-like phosphatase domain