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    Defa24 defensin alpha 24 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290856, updated on 27-Nov-2024

    Summary

    Official Symbol
    Defa24provided by RGD
    Official Full Name
    defensin alpha 24provided by RGD
    Primary source
    RGD:1304852
    See related
    EnsemblRapid:ENSRNOG00000030524 AllianceGenome:RGD:1304852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rd5; Defcr4; Defcr24; defensin 6; defensin 7; defensin-5
    Summary
    Predicted to be involved in cellular response to lipopolysaccharide; defense response to other organism; and disruption of plasma membrane integrity in another organism. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA1 (defensin alpha 1); DEFA1B (defensin alpha 1B); and DEFA3 (defensin alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 1.2), Liver (RPKM 0.8) and 2 other tissues See more
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    Genomic context

    See Defa24 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77052014..77053046, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70349550..70350582, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75345086..75346122, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene defensin beta 1 Neighboring gene defensin alpha 5 Neighboring gene defensin alpha-like 1 Neighboring gene defensin alpha 5, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    defensin 5
    Names
    RD-5
    alpha-defensin, 24
    defensin related cryptdin 24
    defensin related cryptdin 4
    enteric defensin alpha 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013053.2NP_001013071.2  defensin 5 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      Q4JEI9, Q6B329
      Related
      ENSRNOP00000018529.2, ENSRNOT00000018529.6
      Conserved Domains (1) summary
      pfam00879
      Location:1649
      Defensin_propep; Defensin propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      77052014..77053046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)