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    Thbs4 thrombospondin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29220, updated on 9-Dec-2024

    Summary

    Official Symbol
    Thbs4provided by RGD
    Official Full Name
    thrombospondin 4provided by RGD
    Primary source
    RGD:62046
    See related
    EnsemblRapid:ENSRNOG00000012471 AllianceGenome:RGD:62046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including fibronectin binding activity; identical protein binding activity; and laminin-1 binding activity. Involved in behavioral response to pain and neuron projection morphogenesis. Located in neuromuscular junction. Orthologous to human THBS4 (thrombospondin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 402.7), Heart (RPKM 44.2) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Thbs4 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (25718219..25760345, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (23983158..24025289, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (22343727..22385855, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein K, pseudogene 2 Neighboring gene serine incorporator 5 Neighboring gene metaxin 3 Neighboring gene uncharacterized LOC108350222

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fibronectin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables laminin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral response to pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in behavioral response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myoblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tissue remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017133.1NP_058829.1  thrombospondin-4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K7L8, F1LMS5
      Related
      ENSRNOP00000074259.1, ENSRNOT00000083531.3
      Conserved Domains (7) summary
      cd00054
      Location:379413
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:591613
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:496531
      TSP3; TSP3 repeat_long [structural motif]
      pfam02412
      Location:497531
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:745942
      TSP_C; Thrombospondin C-terminal region
      cd16080
      Location:219262
      TSP-4cc; Coiled coil region of thrombospondin-4 (TSP-4)
      cl22861
      Location:24192
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      25718219..25760345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)