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    Defa5 defensin alpha 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286995, updated on 27-Nov-2024

    Summary

    Official Symbol
    Defa5provided by RGD
    Official Full Name
    defensin alpha 5provided by RGD
    Primary source
    RGD:727951
    See related
    EnsemblRapid:ENSRNOG00000030093 AllianceGenome:RGD:727951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Defa; ratNP-1; ratNP-2
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of interleukin-8 production; and protein homotetramerization. Predicted to be located in midbody and secretory granule. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA5 (defensin alpha 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 522.4) See more
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    Genomic context

    See Defa5 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77044994..77047318, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70342530..70344854, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75338050..75340401, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene defensin beta 50 Neighboring gene defensin beta 1 Neighboring gene defensin alpha 24 Neighboring gene defensin alpha-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in defense response to fungus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in disruption of plasma membrane integrity in another organism IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response in mucosa IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in killing by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of membrane permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neutrophil antibiotic peptide NP-2
    Names
    alpha-defensin 5, Paneth cell-specific
    defensin NP-2
    defensin, alpha 5, Paneth cell-specific
    neutrophil antibiotic peptide NP-1
    neutrophil defensin 1
    neutrophil defensin 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173329.3NP_775451.2  neutrophil antibiotic peptide NP-2 precursor

      See identical proteins and their annotated locations for NP_775451.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q62715, Q62716
      UniProtKB/TrEMBL
      A6IW96
      Related
      ENSRNOP00000018501.1, ENSRNOT00000018501.5
      Conserved Domains (2) summary
      pfam00323
      Location:6593
      Defensin_1; Mammalian defensin
      pfam00879
      Location:151
      Defensin_propep; Defensin propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      77044994..77047318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)