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    Adam22 ADAM metallopeptidase domain 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 57033, updated on 3-Dec-2024

    Summary

    Symbol
    Adam22provided by RGD
    Full Name
    ADAM metallopeptidase domain 22provided by RGD
    Primary source
    RGD:1585016
    See related
    EnsemblRapid:ENSRNOG00000042478 AllianceGenome:RGD:1585016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MDC2
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in positive regulation of protein localization. Located in axon initial segment. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 418.8), Kidney (RPKM 61.5) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Adam22 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (26670984..26925843)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (25716055..25970932)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22864485..23002969)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RUN domain containing 3B Neighboring gene solute carrier family 25, member 40 Neighboring gene DBF4-CDC7 kinase regulatory subunit Neighboring gene transfer RNA proline (anticodon AGG) 72 Neighboring gene uncharacterized LOC120102223 Neighboring gene sorcin Neighboring gene uncharacterized LOC134486721 Neighboring gene STEAP4 metalloreductase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 22
    Names
    a disintegrin and metalloprotease domain (ADAM) 22
    a disintegrin and metalloprotease domain 22
    disintegrin and metalloproteinase domain-containing protein 22-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427457.1NP_001414386.1  disintegrin and metalloproteinase domain-containing protein 22 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6G7Y5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      26670984..26925843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286647.1XP_063142717.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X14

      UniProtKB/TrEMBL
      A0A8I6G6D0
    2. XM_039108561.1XP_038964489.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G7Y5
      Conserved Domains (4) summary
      smart00050
      Location:450525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70185
      Pep_M12B_propep; Reprolysin family propeptide
    3. XM_039108564.1XP_038964492.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y6E8, A0A8I6G7Y5
      Related
      ENSRNOP00000077847.1, ENSRNOT00000099765.2
      Conserved Domains (4) summary
      smart00050
      Location:450525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70185
      Pep_M12B_propep; Reprolysin family propeptide
    4. XM_039108563.1XP_038964491.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G7Y5
      Related
      ENSRNOP00000059289.5, ENSRNOT00000068410.6
      Conserved Domains (4) summary
      smart00050
      Location:450525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70185
      Pep_M12B_propep; Reprolysin family propeptide
    5. XM_039108565.2XP_038964493.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G7Y5
      Related
      ENSRNOP00000064723.4, ENSRNOT00000073501.5
      Conserved Domains (4) summary
      smart00050
      Location:450525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70185
      Pep_M12B_propep; Reprolysin family propeptide
    6. XM_039108567.2XP_038964495.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G6D0
      Related
      ENSRNOP00000094391.2, ENSRNOT00000101856.2
      Conserved Domains (4) summary
      smart00050
      Location:450525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70185
      Pep_M12B_propep; Reprolysin family propeptide
    7. XM_063286643.1XP_063142713.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G6D0
    8. XM_039108569.2XP_038964497.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

      UniProtKB/TrEMBL
      A0A8I6G6D0
      Related
      ENSRNOP00000093947.2, ENSRNOT00000094468.2
      Conserved Domains (4) summary
      smart00050
      Location:450525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70185
      Pep_M12B_propep; Reprolysin family propeptide
    9. XM_063286645.1XP_063142715.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

      UniProtKB/TrEMBL
      A0A8I6G6D0, A0A8I6GKI4
      Related
      ENSRNOP00000081703.1, ENSRNOT00000108037.2
    10. XM_039108568.2XP_038964496.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AMW2, A0A8I6G7Y5
      Related
      ENSRNOP00000094323.1, ENSRNOT00000111685.2
      Conserved Domains (4) summary
      smart00050
      Location:450525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70185
      Pep_M12B_propep; Reprolysin family propeptide
    11. XM_063286644.1XP_063142714.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

      UniProtKB/TrEMBL
      A0A8I6G7Y5
    12. XM_039108571.2XP_038964499.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

      UniProtKB/TrEMBL
      A0A8I6G6D0, F1M542
      Conserved Domains (4) summary
      smart00050
      Location:450525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70185
      Pep_M12B_propep; Reprolysin family propeptide
    13. XM_039108572.2XP_038964500.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

      UniProtKB/TrEMBL
      A0A8I6G6D0
      Related
      ENSRNOP00000085571.2, ENSRNOT00000114747.2
      Conserved Domains (4) summary
      smart00050
      Location:450525
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:527668
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:236435
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:70185
      Pep_M12B_propep; Reprolysin family propeptide
    14. XM_063286646.1XP_063142716.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

    RNA

    1. XR_010065701.1 RNA Sequence

    2. XR_005503424.2 RNA Sequence

    3. XR_010065699.1 RNA Sequence

    4. XR_010065700.1 RNA Sequence