Crtc2 CREB regulated transcription coactivator 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crtc2provided by RGD
Official Full Name: CREB regulated transcription coactivator 2provided by RGD
Primary source: RGD:1308903
See related: EnsemblRapid:ENSRNOG00000056337 AllianceGenome:RGD:1308903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Torc2; RGD1308903
Summary: Enables chromatin binding activity. Predicted to be involved in several processes, including cellular response to cAMP; gluconeogenesis; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Used to study type 2 diabetes mellitus. Orthologous to human CRTC2 (CREB regulated transcription coactivator 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 54.4), Thymus (RPKM 46.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (178007233..178017397)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (175709603..175719768)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (189615928..189625646)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRTC2 and Nedd4 ligase involvement in FSH and TGFbeta1 upregulation of connexin43 gap junction
Title: CRTC2 and Nedd4 ligase involvement in FSH and TGFβ1 upregulation of connexin43 gap junction.
Results indicate that overexpressing SIK1 can phosphorylate CRTC1 and CRTC2 in the norepinephrine (NE)-stimulated pinealocytes. Howeve, the endogenous SIK1 does not appear to be the main regulator of their phosphorylation and intracellular localization.
Title: The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and cellular distribution is independent of endogenous SIK1 in the male rat pinealocyte.
Berberine inhibited hepatic gluconeogenesis via the regulation of the LKB1-AMPK-TORC2 signaling pathway.
Title: Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.
These data suggest mTORC2 phosphorylation of Akt is a key mediator of H2S-induced cardioprotection in I/R.
Title: mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection.
Suggest that CRTC2 participates in CREB-dependent photic entrainment of suprachiasmatic nucleus function.
Title: CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure.
CRTC2 inhibition resulted in reduced expression of several glucagon-induced pyridoxal 5'-phosphate-dependent enzymes that convert amino acids to gluconeogenic intermediates
Title: cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.
CRTC2 and calcineurin are critical signaling mediators in FSH and TGFbeta1-stimulated steroidogenesis in ovarian granulosa cells.
Title: CREB coactivator CRTC2/TORC2 and its regulator calcineurin crucially mediate follicle-stimulating hormone and transforming growth factor β1 upregulation of steroidogenesis.
The differential distribution patterns are consistent with complex roles for TORC1, -2, and -3 isoforms in diverse brain structures.
Title: The distribution of messenger RNAs encoding the three isoforms of the transducer of regulated cAMP responsive element binding protein activity in the rat forebrain.
Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling
Title: Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling.
TORC2 translocates to the nucleus of hypothalamic CRH neurones and interacts with the CRH promoter in conjunction with the activation of CRH transcription during restraint stress.
Title: Stress induces parallel changes in corticotrophin-releasing hormone (CRH) Transcription and nuclear translocation of transducer of regulated cAMP response element-binding activity 2 in hypothalamic CRH neurones.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Crtc2 (e-PCR), detects polymorphism
- UniSTS:547204

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cAMP response element binding protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding protein binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CREB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CREB-regulated transcription coactivator 2

Names: TORC-2; transducer of CREB protein 2; transducer of regulated cAMP response element-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033895.2 → NP_001029067.1 CREB-regulated transcription coactivator 2

See identical proteins and their annotated locations for NP_001029067.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q3LRZ1

UniProtKB/TrEMBL

A0A8L2R0S0, B4F7E3

Conserved Domains (3) summary

pfam12884
Location:18 → 72

TORC_N; Transducer of regulated CREB activity, N-terminus

pfam12885
Location:168 → 316

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:613 → 690

TORC_C; Transducer of regulated CREB activity, C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

178007233..178017397

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281829.1 → XP_063137899.1 CREB-regulated transcription coactivator 2 isoform X5
XM_063281828.1 → XP_063137898.1 CREB-regulated transcription coactivator 2 isoform X4

UniProtKB/TrEMBL

A0A8L2R0S0
XM_063281825.1 → XP_063137895.1 CREB-regulated transcription coactivator 2 isoform X1

UniProtKB/TrEMBL

A0A8L2R0S0
XM_063281826.1 → XP_063137896.1 CREB-regulated transcription coactivator 2 isoform X2

UniProtKB/Swiss-Prot

Q3LRZ1

UniProtKB/TrEMBL

A0A8L2R0S0, B4F7E3

Related

ENSRNOP00000068813.2, ENSRNOT00000092144.3
XM_063281827.1 → XP_063137897.1 CREB-regulated transcription coactivator 2 isoform X3

UniProtKB/TrEMBL

A0A8L2R0S0