Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Map4k3provided by RGD
Official Full Name: mitogen-activated protein kinase kinase kinase kinase 3provided by RGD
Primary source: RGD:621280
See related: EnsemblRapid:ENSRNOG00000007172 AllianceGenome:RGD:621280
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to be active in cytoplasm. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 225.0), Lung (RPKM 194.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (20029246..20198583)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (14276623..14446321)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (3276732..3444519, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAP4K3 positively regulates preterm skeletal muscle satellite cell myogenesis, but may not regulate mTORC1 activity. MAP4K3 may play a role in mTORC1 full activation in response to leucine.
Title: Roles of Mitogen-Activating Protein Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Regulation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127652 (e-PCR)
- UniSTS:210962

RH131821 (e-PCR)
- UniSTS:215104

D6Rat56 (e-PCR)
- UniSTS:119392

PMC16375P1 (e-PCR)
- UniSTS:271478

AU046365 (e-PCR)
- UniSTS:111511

AU047952 (e-PCR)
- UniSTS:110018

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to UV	IEA Inferred from Electronic Annotation more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase kinase 3

Names: GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3; germinal center kinase-related protein kinase

NP_596898.1

EC 2.7.11.1

XP_006239718.2

EC 2.7.11.1

XP_017449508.2

EC 2.7.11.1

XP_017449509.2

EC 2.7.11.1

XP_017449510.2

EC 2.7.11.1

XP_038967654.1

EC 2.7.11.1

XP_038967655.1

EC 2.7.11.1

XP_038967656.1

EC 2.7.11.1

XP_038967657.1

EC 2.7.11.1

XP_038967658.1

EC 2.7.11.1

XP_038967659.1

EC 2.7.11.1

XP_038967660.1

EC 2.7.11.1

XP_038967661.1

EC 2.7.11.1

XP_063117574.1

EC 2.7.11.1

XP_063117575.1

EC 2.7.11.1

XP_063117576.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133407.1 → NP_596898.1 mitogen-activated protein kinase kinase kinase kinase 3

See identical proteins and their annotated locations for NP_596898.1

Status: VALIDATED

Source sequence(s)

AA819812, AF312224, AI502900, CK474868, DV716943

UniProtKB/Swiss-Prot

Q924I2

UniProtKB/TrEMBL

A6H9Q1, R9PXT4

Conserved Domains (3) summary

smart00036
Location:540 → 853

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:16 → 273

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06613
Location:15 → 273

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

20029246..20198583

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111726.2 → XP_038967654.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X1

UniProtKB/TrEMBL

A0A8I6AV17

Conserved Domains (2) summary

smart00036
Location:583 → 926

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:15 → 273

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_039111728.2 → XP_038967656.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X4

UniProtKB/TrEMBL

R9PXT4

Conserved Domains (2) summary

smart00036
Location:562 → 905

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:15 → 273

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_039111729.2 → XP_038967657.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X6

UniProtKB/TrEMBL

A0A8I6AV17

Conserved Domains (2) summary

smart00036
Location:583 → 896

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:15 → 273

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_039111727.2 → XP_038967655.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X3

UniProtKB/TrEMBL

A0A8I6AV17

Conserved Domains (2) summary

smart00036
Location:572 → 915

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:15 → 273

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_017594019.3 → XP_017449508.2 mitogen-activated protein kinase kinase kinase kinase 3 isoform X2

UniProtKB/TrEMBL

A0A8I6AV17

Conserved Domains (2) summary

smart00036
Location:572 → 915

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:15 → 273

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_017594021.3 → XP_017449510.2 mitogen-activated protein kinase kinase kinase kinase 3 isoform X7

UniProtKB/TrEMBL

R9PXT4

Conserved Domains (2) summary

smart00036
Location:551 → 894

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:15 → 273

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_017594020.3 → XP_017449509.2 mitogen-activated protein kinase kinase kinase kinase 3 isoform X5

UniProtKB/TrEMBL

A0A8I6AV17

Related

ENSRNOP00000090754.2, ENSRNOT00000110847.2

Conserved Domains (2) summary

smart00036
Location:561 → 904

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:15 → 273

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_063261505.1 → XP_063117575.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X9

UniProtKB/TrEMBL

R9PXT4

Related

ENSRNOP00000010366.8, ENSRNOT00000010366.9
XM_063261504.1 → XP_063117574.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X8

UniProtKB/TrEMBL

A0A8I6AV17

Related

ENSRNOP00000069683.3, ENSRNOT00000084602.3
XM_006239656.5 → XP_006239718.2 mitogen-activated protein kinase kinase kinase kinase 3 isoform X10

UniProtKB/TrEMBL

A0A0G2JVZ8, A0A8I6AV17

Related

ENSRNOP00000097492.1, ENSRNOT00000118971.2

Conserved Domains (2) summary

smart00036
Location:561 → 874

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:15 → 273

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_039111730.2 → XP_038967658.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X11

UniProtKB/TrEMBL

R9PXT4

Conserved Domains (2) summary

smart00036
Location:551 → 864

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:15 → 273

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_039111731.2 → XP_038967659.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X12

UniProtKB/TrEMBL

A0A0G2JYP2

Conserved Domains (2) summary

smart00036
Location:520 → 863

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06613
Location:1 → 210

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
XM_039111732.1 → XP_038967660.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X14

UniProtKB/TrEMBL

A0A0G2JYP2

Conserved Domains (2) summary

smart00036
Location:494 → 837

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:1 → 184

PKc_like; Protein Kinases, catalytic domain
XM_063261506.1 → XP_063117576.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X13

UniProtKB/TrEMBL

A0A0G2JYP2
XM_039111733.2 → XP_038967661.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X15

UniProtKB/TrEMBL

A0A0G2JYP2

Conserved Domains (2) summary

smart00036
Location:406 → 749

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cl21453
Location:1 → 96

PKc_like; Protein Kinases, catalytic domain