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    Las1l LAS1-like, ribosome biogenesis factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Las1lprovided by RGD
    Official Full Name
    LAS1-like, ribosome biogenesis factorprovided by RGD
    Primary source
    RGD:1565755
    See related
    EnsemblRapid:ENSRNOG00000021748 AllianceGenome:RGD:1565755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565755
    Summary
    Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be located in nucleolus. Predicted to be part of MLL1 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 103.2), Spleen (RPKM 100.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Las1l in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (64861472..64883221, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (60851969..60873717, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (65081591..65102344, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X Unlocalized Scaffold NW_007906386.1 (10516..11640, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 12B Neighboring gene alpha- and gamma-adaptin binding protein, pseudogene 1 Neighboring gene DLG associated protein 4, pseudogene 1 Neighboring gene uncharacterized LOC102550969 Neighboring gene small Cajal body-specific RNA 3 Neighboring gene moesin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Dou Y, et al. Cell, 2005 Jun 17. PMID 15960975
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC189399

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Las1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal biogenesis protein LAS1L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170590.1 → NP_001164061.1  ribosomal biogenesis protein LAS1L

      Status: VALIDATED

      Source sequence(s)
      BF554409, CB322360, CB751131, CB811034, FM042988, JAXUCZ010000021
      UniProtKB/TrEMBL
      F7FJR8
      Conserved Domains (1) summary
      pfam04031
      Location:28 → 172
      Las1; Las1-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      64861472..64883221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099569.2 → XP_038955497.1  ribosomal biogenesis protein LAS1L isoform X1

      UniProtKB/TrEMBL
      F7FJR8
      Conserved Domains (1) summary
      pfam04031
      Location:28 → 171
      Las1; Las1-like

    2. XM_039099571.2 → XP_038955499.1  ribosomal biogenesis protein LAS1L isoform X3

      UniProtKB/TrEMBL
      F7FJR8
      Related
      ENSRNOP00000016042.7, ENSRNOT00000016042.10
      Conserved Domains (1) summary
      pfam04031
      Location:28 → 171
      Las1; Las1-like

    3. XM_063279874.1 → XP_063135944.1  ribosomal biogenesis protein LAS1L isoform X5

      UniProtKB/TrEMBL
      A0A8I6A8V8, F7FJR8
      Related
      ENSRNOP00000090181.1, ENSRNOT00000076543.3

    4. XM_039099570.2 → XP_038955498.1  ribosomal biogenesis protein LAS1L isoform X2

      UniProtKB/TrEMBL
      A0A096MJM8, F7FJR8
      Related
      ENSRNOP00000068191.2, ENSRNOT00000076732.4
      Conserved Domains (1) summary
      pfam04031
      Location:28 → 171
      Las1; Las1-like

    5. XM_039099572.2 → XP_038955500.1  ribosomal biogenesis protein LAS1L isoform X4

      UniProtKB/TrEMBL
      F7FJR8
      Conserved Domains (1) summary
      pfam04031
      Location:28 → 171
      Las1; Las1-like
    Nucleotide Protein Strain
    Heading Accession and Version

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