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    Brd4 bromodomain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362844, updated on 3-Dec-2024

    Summary

    Official Symbol
    Brd4provided by RGD
    Official Full Name
    bromodomain containing 4provided by RGD
    Primary source
    RGD:1307282
    See related
    EnsemblRapid:ENSRNOG00000006770 AllianceGenome:RGD:1307282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including P-TEFb complex binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation by host of viral transcription; positive regulation of T-helper 17 cell lineage commitment; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including inner cell mass cell proliferation; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in chromatin; condensed nuclear chromosome; and nucleoplasm. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 6; colon cancer; and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 67.3), Thymus (RPKM 60.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Brd4 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (11866997..11946575, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11216446..11296029, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14222101..14303055, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene notch receptor 3 Neighboring gene epoxide hydrolase 3 Neighboring gene uncharacterized LOC134479823 Neighboring gene A-kinase anchoring protein 8 Neighboring gene A-kinase anchoring protein 8 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables P-TEFb complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II C-terminal domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner cell mass cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 17 cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin/CDK positive transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bromodomain-containing protein 4
    NP_001094373.1
    XP_006241134.1
    XP_006241135.1
    XP_008763393.2
    XP_017450405.1
    XP_038935343.1
    XP_038935344.1
    XP_063119821.1
    XP_063119822.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100903.1NP_001094373.1  bromodomain-containing protein 4

      See identical proteins and their annotated locations for NP_001094373.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D3ZGX8
      Related
      ENSRNOP00000070799.2, ENSRNOT00000091368.3
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:354455
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:610674
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13611403
      BRD4_CDT; C-terminal domain of bromodomain protein 4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      11866997..11946575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263751.1XP_063119821.1  bromodomain-containing protein 4 isoform X4

      UniProtKB/TrEMBL
      D3ZGX8
    2. XM_008765171.4XP_008763393.2  bromodomain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      D3ZGX8
    3. XM_017594916.3XP_017450405.1  bromodomain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYV0, D3ZGX8
      Related
      ENSRNOP00000008963.8, ENSRNOT00000008963.9
    4. XM_006241072.5XP_006241134.1  bromodomain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006241134.1

      UniProtKB/TrEMBL
      D3ZGX8
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:354455
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:610674
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13611403
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    5. XM_006241073.5XP_006241135.1  bromodomain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006241135.1

      UniProtKB/TrEMBL
      D3ZGX8
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:354455
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:610674
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13611403
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    6. XM_063263752.1XP_063119822.1  bromodomain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      D3ZGX8
    7. XM_039079415.2XP_038935343.1  bromodomain-containing protein 4 isoform X5

      UniProtKB/TrEMBL
      D3ZGX8
      Conserved Domains (4) summary
      cd05498
      Location:206307
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      PHA03247
      Location:6531101
      PHA03247; large tegument protein UL36; Provisional
      pfam17035
      Location:462526
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:12131255
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    8. XM_039079416.2XP_038935344.1  bromodomain-containing protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZKZ4, A6K943
      Related
      ENSRNOP00000078464.1, ENSRNOT00000095545.2
      Conserved Domains (3) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:354455
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:610674
      BET; Bromodomain extra-terminal - transcription regulation