Tmem97 transmembrane protein 97 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem97provided by RGD
Official Full Name: transmembrane protein 97provided by RGD
Primary source: RGD:1307423
See related: AllianceGenome:RGD:1307423
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307423
Summary: Predicted to enable cholesterol binding activity and oxysterol binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; positive regulation of lipoprotein transport; and regulation of intracellular cholesterol transport. Predicted to be located in several cellular components, including lysosome; nuclear membrane; and rough endoplasmic reticulum. Predicted to be active in endoplasmic reticulum. Orthologous to human TMEM97 (transmembrane protein 97). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 404.4), Liver (RPKM 260.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63936276..63945359, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (63438228..63447311, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (65811455..65820538, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH128845 (e-PCR)
- UniSTS:212153

D11Seg37 (e-PCR), detects polymorphism
- UniSTS:141812

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cholesterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxysterol binding	ISO Inferred from Sequence Orthology more info
enables oxysterol binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipoprotein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of intracellular lipid transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular lipid transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in rough endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sigma intracellular receptor 2

Names: sigma-2 receptor; sigma2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008334.1 → NP_001008335.1 sigma intracellular receptor 2

See identical proteins and their annotated locations for NP_001008335.1

Status: PROVISIONAL

Source sequence(s)

BC085344

UniProtKB/Swiss-Prot

Q5U3Y7

UniProtKB/TrEMBL

A6HH65

Conserved Domains (1) summary

pfam10914
Location:12 → 150

DUF2781; Protein of unknown function (DUF2781)