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    Defa7 defensin alpha 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 613222, updated on 27-Nov-2024

    Summary

    Symbol
    Defa7provided by RGD
    Full Name
    defensin alpha 7provided by RGD
    Primary source
    RGD:1560529
    See related
    AllianceGenome:RGD:1560529
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in defense response to bacterium; defense response to fungus; and killing of cells of another organism. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Restricted expression toward (RPKM 102.3) See more
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    Genomic context

    See Defa7 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77121608..77133013, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70419152..70430555, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75414786..75415555, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene defensin alpha-like 1, pseudogene 1 Neighboring gene defensin alpha 6 Neighboring gene defensin alpha 8 Neighboring gene defensin alpha 5, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to fungus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033075.2NP_001028247.1  alpha-defensin 7 precursor

      See identical proteins and their annotated locations for NP_001028247.1

      Status: VALIDATED

      Source sequence(s)
      AY623751, JAXUCZ010000016
      UniProtKB/TrEMBL
      F1LQB7, Q4JEI7
      Conserved Domains (2) summary
      pfam00323
      Location:6795
      Defensin_1; Mammalian defensin
      pfam00879
      Location:1853
      Defensin_propep; Defensin propeptide

    RNA

    1. NR_172012.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant (1, coding) but represents the allele present on the mRatBN7.2 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      JAXUCZ010000016

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      77121608..77133013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)