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    RatNP-3b defensin RatNP-3 precursor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498659, updated on 27-Nov-2024

    Summary

    Symbol
    RatNP-3bprovided by RGD
    Full Name
    defensin RatNP-3 precursorprovided by RGD
    Primary source
    RGD:1589653
    See related
    EnsemblRapid:ENSRNOG00000038135 AllianceGenome:RGD:1589653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Np3; NP-3; NP-3a; NP-3b
    Summary
    Predicted to be involved in defense response to fungus and killing of cells of another organism. Orthologous to several human genes including DEFA5 (defensin alpha 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 280.9) See more
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    Genomic context

    See RatNP-3b in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (77246811..77248977, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (70544364..70546533, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (75528348..75530511, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene defensin alpha 31 Neighboring gene defensin alpha 3 Neighboring gene defensin beta 51 Neighboring gene uncharacterized LOC134482413

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    neutrophil antibiotic peptide NP-3B
    Names
    Neutrophil antibiotic peptide NP-3A
    defensin 3a
    defensin 3b
    defensin NP-3
    neutrophil antibiotic peptide NP-3
    neutrophil defensin 3
    ratNP-3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079898.4NP_001073367.2  neutrophil antibiotic peptide NP-3B precursor

      See identical proteins and their annotated locations for NP_001073367.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q62713, Q9Z1F1
      UniProtKB/TrEMBL
      A6IWA0
      Related
      ENSRNOP00000098274.1, ENSRNOT00000120639.2
      Conserved Domains (2) summary
      pfam00323
      Location:5987
      Defensin_1; Mammalian defensin
      pfam00879
      Location:1645
      Defensin_propep; Defensin propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      77246811..77248977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)