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    Pld1 phospholipase D1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25096, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pld1provided by RGD
    Official Full Name
    phospholipase D1provided by RGD
    Primary source
    RGD:3349
    See related
    EnsemblRapid:ENSRNOG00000028156 AllianceGenome:RGD:3349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plda; Pldb; Pld1a; Pld1b
    Summary
    Enables phospholipase D activity. Involved in phospholipid catabolic process; positive regulation of cell migration; and response to peptide hormone. Acts upstream of or within phosphatidic acid biosynthetic process. Located in Golgi cisterna; lamellipodium; and vesicle. Is active in synapse. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 150.5), Lung (RPKM 47.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pld1 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (112777820..112975857)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (110849205..111047304)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (113651967..113849403)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene uncharacterized LOC102555566 Neighboring gene transmembrane protein 212 Neighboring gene uncharacterized LOC120100789 Neighboring gene ribosomal protein L15, pseudogene 12 Neighboring gene uncharacterized LOC120100791 Neighboring gene uncharacterized LOC120100792

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase D activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase D activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase D activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phosphatidic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microvillus assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of microvillus assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to peptide hormone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi cisterna IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cholinergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    phospholipase D1
    Names
    PLD 1
    Phoshpolipase D gene 1 probably with two splicing variants A and B
    choline phosphatase 1
    phosphatidylcholine-hydrolyzing phospholipase D1
    phospholipase D gene 1, probably with two splicing variants A and B
    phospholipase D1, phosphatidylcholine-specific
    rPLD1
    NP_001386011.1
    NP_112254.2
    XP_006232268.1
    XP_063137387.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399082.1NP_001386011.1  phospholipase D1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O08959, O35856, O54765, P70496, P70497, Q9QWJ6
      UniProtKB/TrEMBL
      F1LMG4
      Related
      ENSRNOP00000034466.4, ENSRNOT00000039296.8
      Conserved Domains (1) summary
      PLN02866
      Location:821059
      PLN02866; phospholipase D
    2. NM_030992.3NP_112254.2  phospholipase D1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6IHH9, D4A318
      Related
      ENSRNOP00000035045.4, ENSRNOT00000039308.6
      Conserved Domains (1) summary
      PLN02866
      Location:821021
      PLN02866; phospholipase D

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      112777820..112975857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232206.5XP_006232268.1  phospholipase D1 isoform X1

      See identical proteins and their annotated locations for XP_006232268.1

      UniProtKB/Swiss-Prot
      O08959, O35856, O54765, P70496, P70497, Q9QWJ6
      UniProtKB/TrEMBL
      F1LMG4
      Conserved Domains (1) summary
      PLN02866
      Location:821059
      PLN02866; phospholipase D
    2. XM_063281317.1XP_063137387.1  phospholipase D1 isoform X2

      UniProtKB/TrEMBL
      A6IHH9, D4A318
      Related
      ENSRNOP00000106851.1, ENSRNOT00000163953.1