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    Abcb1a ATP binding cassette subfamily B member 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170913, updated on 3-Dec-2024

    Summary

    Official Symbol
    Abcb1aprovided by RGD
    Official Full Name
    ATP binding cassette subfamily B member 1Aprovided by RGD
    Primary source
    RGD:619951
    See related
    EnsemblRapid:ENSRNOG00000008012 AllianceGenome:RGD:619951
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abcb1; Mdr1a
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including cellular hyperosmotic salinity response; cellular response to L-glutamate; and cellular response to borneol. Located in apical plasma membrane and brush border membrane. Biomarker of brain disease (multiple); end stage renal disease; human immunodeficiency virus infectious disease; liver disease (multiple); and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 100.7), Kidney (RPKM 76.4) and 9 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Abcb1a in Genome Data Viewer
    Location:
    4q12
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (26312403..26488456, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (25357467..25529941, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22339829..22517642, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein C11orf98 homolog Neighboring gene uncharacterized LOC120102221 Neighboring gene ATP binding cassette subfamily B member 4 Neighboring gene uncharacterized LOC120102222 Neighboring gene ATP-binding cassette, sub-family B member 1B Neighboring gene RUN domain containing 3B Neighboring gene solute carrier family 25, member 40 Neighboring gene DBF4-CDC7 kinase regulatory subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxylic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ceramide floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine floppase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylethanolamine flippase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carboxylic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular hyperosmotic salinity response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to L-glutamate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to alkaloid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to borneol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to external biotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to mycotoxin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nonylphenol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ceramide translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in daunorubicin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of blood-retinal barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in hormone transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intestinal absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lactation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in maintenance of blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of sensory perception of pain IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in placenta development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of establishment of Sertoli cell barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to bicellular tight junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of chloride transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of intestinal absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to L-glutamate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to alcohol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to antineoplastic agent IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to codeine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to cyclosporin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to dexamethasone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucagon IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glycoside IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to mycotoxin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to quercetin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to thyroxine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in terpenoid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transepithelial transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport across blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in xenobiotic transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP binding cassette subfamily B member 1A
    Names
    ATP binding cassette subfamily B member 1
    ATP-binding cassette, sub-family B (MDR/TAP), member 1
    ATP-binding cassette, sub-family B (MDR/TAP), member 1A
    ATP-binding cassette, subfamily B (MDR/TAP), member 1A
    multiple drug resistant 1a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133401.2NP_596892.1  ATP binding cassette subfamily B member 1A

      See identical proteins and their annotated locations for NP_596892.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2KA64, A0A9K3Y745, Q6PSM0, Q9JK64
      Related
      ENSRNOP00000098458.1, ENSRNOT00000120846.2
      Conserved Domains (3) summary
      cd03249
      Location:385621
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:511259
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:54335
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      26312403..26488456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235994.5XP_006236056.1  ATP binding cassette subfamily B member 1A isoform X1

      See identical proteins and their annotated locations for XP_006236056.1

      UniProtKB/TrEMBL
      A0A0G2KA64, A0A9K3Y745, Q6PSM0, Q9JK64
      Conserved Domains (3) summary
      cd03249
      Location:385621
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      PTZ00265
      Location:511259
      PTZ00265; multidrug resistance protein (mdr1); Provisional
      pfam00664
      Location:54335
      ABC_membrane; ABC transporter transmembrane region
    2. XM_063285445.1XP_063141515.1  ATP binding cassette subfamily B member 1A isoform X2

      UniProtKB/TrEMBL
      Q6PSM0
      Related
      ENSRNOP00000042556.2, ENSRNOT00000043822.3