Naip1 NLR family, apoptosis inhibitory protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Naip1provided by MGI
Official Full Name: NLR family, apoptosis inhibitory protein 1provided by MGI
Primary source: MGI:MGI:1298223
See related: Ensembl:ENSMUSG00000021640 AllianceGenome:MGI:1298223
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Naip; Birc1a; D13Lsd1; Naip-rs1
Summary: Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in negative regulation of apoptotic process and negative regulation of cysteine-type endopeptidase activity. Acts upstream of or within cellular response to estrogen stimulus and negative regulation of epithelial cell apoptotic process. Located in basolateral plasma membrane and cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and limb. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 14.0), colon adult (RPKM 12.4) and 2 other tissues See more
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Genomic context

Location:: 13 D1; 13 53.18 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (100544272..100589372, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (100407770..100452864, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis.
Title: Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis.
Inflammasome activation and CCR2-mediated monocyte-derived dendritic cell recruitment restrict Legionella pneumophila infection.
Title: Inflammasome activation and CCR2-mediated monocyte-derived dendritic cell recruitment restrict Legionella pneumophila infection.
Naip1 is uniquely required to detect T3SS needle protein and Naip2 is uniquely required to detect T3SS inner rod protein, but neither Naip1 nor Naip2 is required for detection of flagellin.
Title: NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo.
These results provide definitive genetic evidence for the important physiological function of NAIPs in antibacterial defense and inflammatory damage-induced lethality in mice.
Title: Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice.
An epithelium-intrinsic defense axis recruits NAIP and the NLRC4 inflammasome to promote removal of epithelial cells compromised by pathogen invasion.
Title: Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa.
NAIP/NLRC4 oligomerize, assembling inflammasomes, in the presence of their cognate bacterial ligands.
Title: Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes.
In this study, the the type III secretion system needle protein protein is identified as the agonist for the orphan murine NAIP1 receptor
Title: Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein.
/NAIP1 and NAIP2/5 formed a large oligomeric complex with NLRC4 in the presence of corresponding bacterial ligands, and could support reconstitution of the NLRC4 inflammasome in a ligand-specific manner.
Title: Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation.
a role for NAIP in increasing the survival of cells undergoing terminal differentiation as well as the possibility that the protein serves as an intestinal pathogen recognition protein was suggested
Title: Distribution of neuronal apoptosis inhibitory protein in human tissues.
systemic administration of kainic acid rapidly elevates expression of mRNA encoding neuronal apoptosis inhibitor protein (NAIP) in the hippocampus and that this increase does not occur in mice that lack TNF receptors.
Title: Kainic acid-induced naip expression in the hippocampus is blocked in mice lacking TNF receptors.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Naip1 (e-PCR), detects polymorphism
- UniSTS:534557

D13Die29a (e-PCR), detects polymorphism
- UniSTS:164903

D13Die3 (e-PCR), detects polymorphism
- UniSTS:141915

Naip1 (e-PCR), detects polymorphism
- UniSTS:256358

AV364616 (e-PCR)
- UniSTS:180591

D13Die31a (e-PCR), detects polymorphism
- UniSTS:186736

Birc1a (e-PCR), detects polymorphism
- UniSTS:143985

Birc1-rs1 (e-PCR), detects polymorphism
- UniSTS:143986

Birc1-rs1 (e-PCR), detects polymorphism
- UniSTS:143987

Naip1 (e-PCR), detects polymorphism
- UniSTS:496020

PMC310929P12 (e-PCR)
- UniSTS:272817

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to estrogen stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_negative_effect regulation of apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of IPAF inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 1a

Names: baculoviral IAP repeat-containing 1a; neuronal apoptosis inhibitory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008670.2 → NP_032696.2 baculoviral IAP repeat-containing protein 1a

See identical proteins and their annotated locations for NP_032696.2

Status: VALIDATED

Source sequence(s)

AF007769, AF135491

Consensus CDS

CCDS26729.1

UniProtKB/Swiss-Prot

A2RT89, Q9JIB5, Q9QWK5, Q9R017

Related

ENSMUSP00000152583.2, ENSMUST00000222155.2

Conserved Domains (6) summary

cd09293
Location:1072 → 1191

AMN1; Antagonist of mitotic exit network protein 1

smart00238
Location:159 → 229

BIR; Baculoviral inhibition of apoptosis protein repeat

smart00382
Location:465 → 600

AAA; ATPases associated with a variety of cellular activities

cd00022
Location:279 → 346

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

sd00034
Location:1132 → 1156

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:464 → 617

NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

100544272..100589372 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157898.1 → XP_036013791.1 baculoviral IAP repeat-containing protein 1a isoform X1

Conserved Domains (6) summary

cd09293
Location:808 → 927

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:868 → 892

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00653
Location:17 → 82

BIR; Inhibitor of Apoptosis domain

pfam05729
Location:200 → 353

NACHT; NACHT domain

pfam17779
Location:423 → 478

NOD2_WH; NOD2 winged helix domain

pfam17889
Location:502 → 608

NLRC4_HD; NLRC4 helical domain