Hmox2 heme oxygenase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hmox2provided by MGI
Official Full Name: heme oxygenase 2provided by MGI
Primary source: MGI:MGI:109373
See related: Ensembl:ENSMUSG00000004070 AllianceGenome:MGI:109373
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HO2; HO-2
Summary: Predicted to enable heme binding activity and heme oxygenase (decyclizing) activity. Predicted to be involved in porphyrin-containing compound catabolic process; response to hypoxia; and response to oxidative stress. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human HMOX2 (heme oxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 136.2), cerebellum adult (RPKM 25.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.46 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (4544225..4584606)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (4726361..4766742)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice.
Title: Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice.
Altered Expression of Heme Oxygenase 2 in Heme Oxygenase 1-deficient Mouse Embryos.
Title: Altered Expression of Heme Oxygenase 2 in Heme Oxygenase 1-deficient Mouse Embryos.
Heme Oxygenase 1 and 2 Differentially Regulate Glucose Metabolism and Adipose Tissue Mitochondrial Respiration: Implications for Metabolic Dysregulation.
Title: Heme Oxygenase 1 and 2 Differentially Regulate Glucose Metabolism and Adipose Tissue Mitochondrial Respiration: Implications for Metabolic Dysregulation.
Aged male mice are hypersensitive to ischemic acute kidney injury and HO-2 mitigates such sensitivity. This protective effect of HO-2 may be mediated, at least in part, by suppression of phosphorylated STAT3-dependent signaling.
Title: Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex.
This study demonstrated that HO-2 is involved in reducing inflammatory responses mediated by macrophages. Downstream factors (TNF-alpha, IL1beta and IL-6) that play a role in the TLR4 signaling pathway were suppressed in HO-2 overexpressing macrophages. HO-2 enhanced the survival of allografted skin.
Title: Heme oxygenase-2 suppresses acute inflammation and improves the survival of skin allografts.
This study demonstrated that Deletion of the heme oxygenase-2 aggravates brain injury following stroma-free hemoglobin-induced
Title: Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.
Data indicate that injury induced heme oxygenase 1 (HO-1) expression in both heme oxygenase 2 (HO-2) knockout and wild type mice.
Title: Delayed cutaneous wound closure in HO-2 deficient mice despite normal HO-1 expression.
HO-2 shRNA and HO-2 overexpression plasmids were used to observe the effect of HO-2 in cerebral microvascular endothelial cells. mRNA and protein levels of TNF-alpha and IL6 were increased and decreased, respectively, compared with control groups.
Title: Heme oxygenase-2 suppress TNF-α and IL6 expression via TLR4/MyD88-dependent signaling pathway in mouse cerebral vascular endothelial cells.
macrophage HO-2 is required for proper macrophage function but is insufficient to correct the impaired healing of the HO-2(-/-) cornea, suggesting that corneal epithelial expression of HO-2 is a key to resolution and repair in wound healing
Title: Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing.
These results demonstrate a sex-specific effect of HO-2 deficiency on the development of renovascular hypertension and its effects on the heart in response to the increase in blood pressure.
Title: Sex-specific effects of heme oxygenase-2 deficiency on renovascular hypertension.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme oxygenase (decyclizing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme oxygenase (decyclizing) activity	ISO Inferred from Sequence Orthology more info
enables heme oxygenase (decyclizing) activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heme catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme oxidation	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heme oxygenase 2

Names: heme oxygenase (decycling) 2

NP_001129538.1

EC 1.14.14.18

NP_001343979.1

EC 1.14.14.18

NP_001365928.1

EC 1.14.14.18

NP_034573.2

EC 1.14.14.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136066.2 → NP_001129538.1 heme oxygenase 2 isoform 1

See identical proteins and their annotated locations for NP_001129538.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK134536, BP769523, BY071995

Consensus CDS

CCDS27924.1

UniProtKB/Swiss-Prot

O70252, O70626

UniProtKB/TrEMBL

Q3U6W4, Q544R7

Related

ENSMUSP00000004172.9, ENSMUST00000004172.15

Conserved Domains (1) summary

pfam01126
Location:30 → 235

Heme_oxygenase; Heme oxygenase
NM_001357050.1 → NP_001343979.1 heme oxygenase 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC166903

UniProtKB/TrEMBL

Q3U6W4

Conserved Domains (1) summary

pfam01126
Location:58 → 263

Heme_oxygenase; Heme oxygenase
NM_001378999.1 → NP_001365928.1 heme oxygenase 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC166903

UniProtKB/TrEMBL

Q3U6W4

Conserved Domains (1) summary

pfam01126
Location:49 → 254

Heme_oxygenase; Heme oxygenase
NM_010443.2 → NP_034573.2 heme oxygenase 2 isoform 1

See identical proteins and their annotated locations for NP_034573.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to transcript variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK134536, BP769523, CA465845

Consensus CDS

CCDS27924.1

UniProtKB/Swiss-Prot

O70252, O70626

UniProtKB/TrEMBL

Q3U6W4, Q544R7

Related

ENSMUSP00000112397.2, ENSMUST00000120232.8

Conserved Domains (1) summary

pfam01126
Location:30 → 235

Heme_oxygenase; Heme oxygenase