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    Aldh3b1 aldehyde dehydrogenase 3 family, member B1 [ Mus musculus (house mouse) ]

    Gene ID: 67689, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Aldh3b1provided by MGI
    Official Full Name
    aldehyde dehydrogenase 3 family, member B1provided by MGI
    Primary source
    MGI:MGI:1914939
    See related
    Ensembl:ENSMUSG00000024885 AllianceGenome:MGI:1914939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALDH4; ALDH7; 1700001N19Rik
    Summary
    Enables aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in aldehyde metabolic process. Predicted to act upstream of or within aldehyde catabolic process and cellular response to oxidative stress. Located in cytosol and plasma membrane. Orthologous to human ALDH3B1 (aldehyde dehydrogenase 3 family member B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 64.8), lung adult (RPKM 33.1) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aldh3b1 in Genome Data Viewer
    Location:
    19 A; 19 3.63 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3963491..3980898, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3913491..3930898, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 Neighboring gene STARR-positive B cell enhancer ABC_E9987 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8 Neighboring gene predicted gene, 42059 Neighboring gene STARR-positive B cell enhancer ABC_E7624 Neighboring gene unc-93 homolog B1, TLR signaling regulator Neighboring gene STARR-seq mESC enhancer starr_45335 Neighboring gene aldehyde dehydrogenase 3 family, member B3 Neighboring gene aldehyde dehydrogenase 3 family, member B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress. Marchitti SA, et al. Free Radic Biol Med, 2010 Nov 15. PMID 20699116, Free PMC Article
    2. Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification. Kitamura T, et al. Biochem J, 2015 Jan 1. PMID 25286108
    3. Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Levi BP, et al. Blood, 2009 Feb 19. PMID 18971422, Free PMC Article
    4. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-chloroallyl aldehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables benzaldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables benzaldehyde dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aldehyde catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aldehyde metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within aldehyde metabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ethanol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldehyde dehydrogenase family 3 member B1
    Names
    aldehyde dehydrogenase 7
    long-chain fatty aldehyde dehydrogenase
    medium-chain fatty aldehyde dehydrogenase
    NP_080592.2
    XP_006531893.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026316.3 → NP_080592.2  aldehyde dehydrogenase family 3 member B1

      See identical proteins and their annotated locations for NP_080592.2

      Status: VALIDATED

      Source sequence(s)
      BC046597, BY194399
      Consensus CDS
      CCDS29403.1
      UniProtKB/Swiss-Prot
      Q63ZW3, Q80VQ0, Q8VHW0, Q9CW05
      UniProtKB/TrEMBL
      Q3TX25, Q3U3J9
      Related
      ENSMUSP00000056276.7, ENSMUST00000051803.8
      Conserved Domains (1) summary
      cd07132
      Location:5 → 447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      3963491..3980898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531830.4 → XP_006531893.1  aldehyde dehydrogenase family 3 member B1 isoform X1

      See identical proteins and their annotated locations for XP_006531893.1

      UniProtKB/Swiss-Prot
      Q63ZW3, Q80VQ0, Q8VHW0, Q9CW05
      UniProtKB/TrEMBL
      Q3TX25, Q3U3J9
      Conserved Domains (1) summary
      cd07132
      Location:5 → 447
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VQ0.1 GenPept UniProtKB/Swiss-Prot:Q80VQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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