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    GPX1 glutathione peroxidase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817046, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GPX1
    Official Full Name
    glutathione peroxidase 1
    Primary source
    TAIR:AT2G25080
    Locus tag
    AT2G25080
    See related
    Araport:AT2G25080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGPX1; F13D4.40; F13D4_40; glutathione peroxidase 1; GLUTATHIONE PEROXIDASE 1
    Summary
    Encodes glutathione peroxidase.
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    Genomic context

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    See GPX1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (10667898..10670127)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 2C family protein Neighboring gene miscRNA Neighboring gene CBL-interacting protein kinase 16 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis chloroplastic glutathione peroxidases play a role in cross talk between photooxidative stress and immune responses. Chang CC, et al. Plant Physiol, 2009 Jun. PMID 19363092, Free PMC Article
    2. Glutathione peroxidase-like enzymes cover five distinct cell compartments and membrane surfaces in Arabidopsis thaliana. Attacha S, et al. Plant Cell Environ, 2017 Aug. PMID 28102911
    3. Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways. Rodriguez Milla MA, et al. Plant J, 2003 Dec. PMID 14617062
    4. Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana. Ferro M, et al. Mol Cell Proteomics, 2003 May. PMID 12766230
    5. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chloroplastic forms of Glutathione peroxidases regulate cellular photooxidative tolerance and immune responses. GPX1 and GPX7 have partially overlapping functions. [GPX1]
      Title: Arabidopsis chloroplastic glutathione peroxidases play a role in cross talk between photooxidative stress and immune responses.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_128065.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phospholipid-hydroperoxide glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    glutathione peroxidase 1
    NP_180080.1
    • glutathione peroxidase 1 (GPX1); FUNCTIONS IN: glutathione peroxidase activity; INVOLVED IN: oxidation reduction, response to oxidative stress; LOCATED IN: chloroplast thylakoid membrane, chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like fold (InterPro:IPR012336), Glutathione peroxidase (InterPro:IPR000889); BEST Arabidopsis thaliana protein match is: glutathione peroxidase 7 (TAIR:AT4G31870.1); Has 7896 Blast hits to 7895 proteins in 1765 species: Archae - 2; Bacteria - 4003; Metazoa - 799; Fungi - 210; Plants - 390; Viruses - 8; Other Eukaryotes - 2484 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10667898..10670127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128065.5 → NP_180080.1  glutathione peroxidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180080.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O19985, O81717, P52032
      UniProtKB/TrEMBL
      A0A178VXY6, A0A5S9X1A3
      Conserved Domains (2) summary
      PLN02399
      Location:1 → 236
      PLN02399; phospholipid hydroperoxide glutathione peroxidase
      pfam00578
      Location:81 → 216
      AhpC-TSA; AhpC/TSA family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52032.2

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