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    TIC110 translocon at the inner envelope membrane of chloroplasts 110 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837205, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TIC110
    Official Full Name
    translocon at the inner envelope membrane of chloroplasts 110
    Primary source
    TAIR:AT1G06950
    Locus tag
    AT1G06950
    See related
    Araport:AT1G06950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA TRANSLOCON AT THE INNER ENVELOPE MEMBRANE OF CHLOROPLASTS 110; ATTIC110; translocon at the inner envelope membrane of chloroplasts 110
    Summary
    Encodes a protein thought to be a part of the translocon at the chloroplast inner envelope. Involved in protein import into the chloroplast and chloroplast biogenesis. C-terminal half of Tic110 functions as scaffolds for protein-protein interactions.
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    Genomic context

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    See TIC110 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Sequence:
    Chromosome: 1; NC_003070.9 (2130053..2135703, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene endonuclease/glycosyl hydrolase Neighboring gene TPRXL Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene cation/hydrogen exchanger 14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stimulation of transit-peptide release and ATP hydrolysis by a cochaperone during protein import into chloroplasts. Chou ML, et al. J Cell Biol, 2006 Dec 18. PMID 17158958, Free PMC Article
    2. Tic20 forms a channel independent of Tic110 in chloroplasts. Kovács-Bogdán E, et al. BMC Plant Biol, 2011 Sep 30. PMID 21961525, Free PMC Article
    3. Stable megadalton TOC-TIC supercomplexes as major mediators of protein import into chloroplasts. Chen LJ, et al. Plant J, 2017 Oct. PMID 28745032
    4. Functional Analysis of the Hsp93/ClpC Chaperone at the Chloroplast Envelope. Flores-Pérez Ú, et al. Plant Physiol, 2016 Jan. PMID 26586836, Free PMC Article
    5. OEP80, an essential protein paralogous to the chloroplast protein translocation channel Toc75, exists as a 70-kD protein in the Arabidopsis thaliana chloroplast outer envelope. Hsu SC, et al. Plant Mol Biol, 2012 Jan. PMID 22094888

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tic20 protein is much less abundant than Tic110 in envelope membranes.
      Title: Tic20 forms a channel independent of Tic110 in chloroplasts.
    2. Tic110 is essential for plastid biogenesis and plant viability. It plays a general role in the import of nuclear-encoded preproteins as a common component of Tic complexes.[atTic110]
      Title: Arabidopsis tic110 is essential for the assembly and function of the protein import machinery of plastids.
    3. The interaction of Tic110, Tic40 and Hsp93 in A. thaliana chloroplast protein transport is described. [Tic110]
      Title: In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100568.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into chloroplast stroma IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TOC-TIC supercomplex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Tic complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    translocon at the inner envelope membrane of chloroplasts 110
    NP_172176.1
    • translocon at the inner envelope membrane of chloroplasts 110 (TIC110); INVOLVED IN: protein import into chloroplast stroma, chloroplast organization; LOCATED IN: chloroplast, membrane, chloroplast envelope, Tic complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; Has 131 Blast hits to 118 proteins in 52 species: Archae - 4; Bacteria - 6; Metazoa - 16; Fungi - 9; Plants - 66; Viruses - 0; Other Eukaryotes - 30 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2130053..2135703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100568.4 → NP_172176.1  translocon at the inner envelope membrane of chloroplasts 110 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172176.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WMF8, Q8LPG5, Q8LPR9, Q9LMI9, Q9M9Z7
      UniProtKB/TrEMBL
      A0A178WFU8, A0A5S9T206
      Conserved Domains (1) summary
      pfam16940
      Location:78 → 650
      Tic110; Chloroplast envelope transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LPR9.1

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