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    MGP3 male gametophyte defective 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843232, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MGP3
    Official Full Name
    male gametophyte defective 3
    Primary source
    TAIR:AT1G68990
    Locus tag
    AT1G68990
    See related
    Araport:AT1G68990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    male gametophyte defective 3; T6L1.17; T6L1_17
    Summary
    MGP3 (male gametophyte-defective 3) belongs to a small family of nuclear-encoded Phage type RNA polymerases (RPOTs) involved in the transcription of mitochondrial genes in Arabidopsis thaliana. Mutation in MGP 3 significantly retarded pollen tube growth and caused defective embryo development.
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    Genomic context

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    See MGP3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (25934997..25940996, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein (DUF295) Neighboring gene tRNA-Phe Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene tRNA-Met Neighboring gene BES1-interacting Myc-like protein 2 Neighboring gene Prolyl oligopeptidase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Arabidopsis nuclear-encoded mitochondrial phage-type RNA polymerase gene RPOTm led to defects in pollen tube growth, female gametogenesis and embryogenesis. Tan XY, et al. Plant Cell Physiol, 2010 Apr. PMID 20231244
    2. Impaired function of the phage-type RNA polymerase RpoTp in transcription of chloroplast genes is compensated by a second phage-type RNA polymerase. Swiatecka-Hagenbruch M, et al. Nucleic Acids Res, 2008 Feb. PMID 18084023, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. evidence for nuclear-encoded RNA polymerases being represented by two phage-type RNA polymerases (RpoTp and RpoTmp) that have overlapping as well as gene-specific functions in the transcription of plastidial genes.
      Title: Impaired function of the phage-type RNA polymerase RpoTp in transcription of chloroplast genes is compensated by a second phage-type RNA polymerase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001198426.1
    NM_105571.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant ovule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    male gametophyte defective 3
    NP_001185355.1
    • male gametophyte defective 3 (MGP3); FUNCTIONS IN: DNA-directed RNA polymerase activity, DNA binding; INVOLVED IN: pollen tube growth, transcription, ovule development, embryo development ending in seed dormancy; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: DNA-directed RNA polymerase, bacteriophage type (InterPro:IPR002092); BEST Arabidopsis thaliana protein match is: DNA/RNA polymerases superfamily protein (TAIR:AT5G15700.1).
    NP_177063.1
    • male gametophyte defective 3 (MGP3); FUNCTIONS IN: DNA-directed RNA polymerase activity, DNA binding; INVOLVED IN: pollen tube growth, transcription, ovule development, embryo development ending in seed dormancy; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: DNA-directed RNA polymerase, bacteriophage type (InterPro:IPR002092); BEST Arabidopsis thaliana protein match is: DNA/RNA polymerases superfamily protein (TAIR:AT5G15700.1); Has 1300 Blast hits to 1282 proteins in 331 species: Archae - 0; Bacteria - 40; Metazoa - 135; Fungi - 222; Plants - 198; Viruses - 137; Other Eukaryotes - 568 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25934997..25940996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105571.4 → NP_177063.1  male gametophyte defective 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177063.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23698, P92969
      UniProtKB/TrEMBL
      A0A5S9WQX5, A0A654EP02
      Conserved Domains (2) summary
      COG5108
      Location:134 → 975
      RPO41; Mitochondrial DNA-directed RNA polymerase [Transcription]
      pfam00940
      Location:585 → 975
      RNA_pol; DNA-dependent RNA polymerase

    2. NM_001198426.1 → NP_001185355.1  male gametophyte defective 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185355.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654EP02, F4I0I3
      Conserved Domains (3) summary
      PHA00452
      Location:135 → 982
      PHA00452; T3/T7-like RNA polymerase
      pfam00940
      Location:592 → 982
      RNA_pol; DNA-dependent RNA polymerase
      pfam14700
      Location:138 → 468
      RPOL_N; DNA-directed RNA polymerase N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92969.1

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