GID1A alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GID1A
Official Full Name: alpha/beta-Hydrolases superfamily protein
Primary source: TAIR:AT3G05120
Locus tag: AT3G05120
See related: Araport:AT3G05120
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGID1A; GA INSENSITIVE DWARF1A; T12H1.8; T12H1_8
Summary: Encodes a gibberellin (GA) receptor ortholog of the rice GA receptor gene (OsGID1). Has GA-binding activity, showing higher affinity to GA4. Interacts with DELLA proteins in vivo in the presence of GA4. The DELLA region alone can interact with GID1A in GA-dependent manner in a Y2H assay.
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Genomic context

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See GID1A in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (1430363..1432844)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

stability negatively regulated by ubiquitination and positively regulated by Tyr phosphorylation
Title: Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation.
The active principle of the gibberellin-binding protein is a GID1 homolog. (Review)
Title: Trails to the gibberellin receptor, GIBBERELLIN INSENSITIVE DWARF1.
Partial after-ripening resulted in increased GID1b, but not GID1a or GID1c mRNA levels.
Title: Loss of Arabidopsis thaliana Seed Dormancy is Associated with Increased Accumulation of the GID1 GA Hormone Receptors.
activated cytosolic GID1A interacts with DELLA proteins before they enter the nucleus and induces a conformational transition that leads to DELLA's deactivation or degradation in the nucleus
Title: Cytosolic activity of the gibberellin receptor GIBBERELLIN INSENSITIVE DWARF1A.
The stronger role of GID1b in non-proteolytic gibberellic acid signaling may result from the fact that GID1b has higher affinity for DELLA protein than GID1a and GID1c.
Title: The roles of the GA receptors GID1a, GID1b, and GID1c in sly1-independent GA signaling.
GID1A plays a major role during fruit-set, whereas GID1B and GID1C have partially redundant function with GID1A in seed development and pod elongation, respectively.
Title: Role of the gibberellin receptors GID1 during fruit-set in Arabidopsis.
GID1 relieves seed dormancy through the down-regulation of DELLA via direct protein-protein interaction.
Title: Lifting della repression of Arabidopsis seed germination by nonproteolytic gibberellin signaling.
Computational simulations are revealing a new gibberellin-binding channel of GID1 and a novel hormone perception mechanism involving only one conformational state of GID1.
Title: Computational gibberellin-binding channel discovery unraveling the unexpected perception mechanism of hormone signal by gibberellin receptor.
Data show the model of the gene expression feedback regulation of GID1, GA20ox, and GA3ox, and DELLA with gibberellin.
Title: Mathematical modeling elucidates the role of transcriptional feedback in gibberellin signaling.
Data propose a possible mechanism that might operate for the transcriptional control of GID1 expression by the circadian clock.
Title: Integrating circadian and gibberellin signaling in Arabidopsis: possible links between the circadian clock and the AtGID1 transcription.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_111384.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables gibberellin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	HEP more info	PubMed
acts_upstream_of_or_within floral organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gibberellin mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of gibberellic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within raffinose family oligosaccharide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to gibberellin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to gibberellin	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: alpha/beta-Hydrolases superfamily protein

NP_187163.1

GA INSENSITIVE DWARF1A (GID1A); FUNCTIONS IN: hydrolase activity; INVOLVED IN: floral organ morphogenesis, raffinose family oligosaccharide biosynthetic process, positive regulation of gibberellic acid mediated signaling pathway, response to gibberellin stimulus, gibberellin mediated signaling pathway; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Lipase, GDXG, active site (InterPro:IPR002168), Alpha/beta hydrolase fold-3 (InterPro:IPR013094); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT5G27320.1); Has 8768 Blast hits to 8750 proteins in 1436 species: Archae - 107; Bacteria - 5145; Metazoa - 395; Fungi - 775; Plants - 1346; Viruses - 3; Other Eukaryotes - 997 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

1430363..1432844

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111384.4 → NP_187163.1 alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_187163.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9MAA7

UniProtKB/TrEMBL

A0A178VM30, A0A5S9X9A6

Conserved Domains (1) summary

pfam07859
Location:109 → 322

Abhydrolase_3; alpha/beta hydrolase fold