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    NP3 NPK1-related protein kinase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819774, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NP3
    Official Full Name
    NPK1-related protein kinase 3
    Primary source
    TAIR:AT3G06030
    Locus tag
    AT3G06030
    See related
    Araport:AT3G06030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ANP3; AtANP3; F24F17.1; F24F17_1; MAPKKK12; NPK1-related protein kinase 3
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    Genomic context

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    See NP3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Sequence:
    Chromosome: 3; NC_003074.8 (1818732..1822858, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene SNF2/Brahma-type chromatin-remodeling protein CHR12 Neighboring gene uncharacterized protein Neighboring gene FANTASTIC four-like protein (DUF3049) Neighboring gene Glycoprotein membrane precursor GPI-anchored Neighboring gene Ribosomal protein L12/ ATP-dependent Clp protease adaptor protein ClpS family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The intracellular ROS accumulation in elicitor-induced immunity requires the multiple organelle-targeted Arabidopsis NPK1-related protein kinases. Marti L, et al. Plant Cell Environ, 2021 Mar. PMID 33314180
    2. Proteomic and biochemical analyses show a functional network of proteins involved in antioxidant defense of the Arabidopsis anp2anp3 double mutant. Takáč T, et al. J Proteome Res, 2014 Dec 5. PMID 25325904, Free PMC Article
    3. Arabidopsis homologs of nucleus- and phragmoplast-localized kinase 2 and 3 and mitogen-activated protein kinase 4 are essential for microtubule organization. Beck M, et al. Plant Cell, 2010 Mar. PMID 20215588, Free PMC Article
    4. AtMPK4 is required for male-specific meiotic cytokinesis in Arabidopsis. Zeng Q, et al. Plant J, 2011 Sep. PMID 21575092
    5. Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system. Nemoto K, et al. Phytochemistry, 2011 Jul. PMID 21477822

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The intracellular ROS accumulation in elicitor-induced immunity requires the multiple organelle-targeted Arabidopsis NPK1-related protein kinases.
      Title: The intracellular ROS accumulation in elicitor-induced immunity requires the multiple organelle-targeted Arabidopsis NPK1-related protein kinases.
    2. Data show that the functional network of proteins involved in antioxidant defense in the MAPK kinase kinases (MAPKKK) anp2anp3 mutant was physiologically linked with the increased resistance of mutant seedlings against paraquat treatment.
      Title: Proteomic and biochemical analyses show a functional network of proteins involved in antioxidant defense of the Arabidopsis anp2anp3 double mutant.
    3. ANP2/ANP3, MPK4, and the MT-associated protein MAP65-1 are involved in microtubule-dependent cell growth mechanisms.
      Title: Arabidopsis homologs of nucleus- and phragmoplast-localized kinase 2 and 3 and mitogen-activated protein kinase 4 are essential for microtubule organization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111477.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NPK1-related protein kinase 3
    NP_187254.1
    • NPK1-related protein kinase 3 (NP3); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: cortical microtubule organization; LOCATED IN: apoplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Mitogen activated protein kinase kinase kinase 3 (InterPro:IPR015748), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NPK1-related protein kinase 1 (TAIR:AT1G09000.1); Has 135037 Blast hits to 132652 proteins in 4867 species: Archae - 156; Bacteria - 15291; Metazoa - 50641; Fungi - 13369; Plants - 33230; Viruses - 554; Other Eukaryotes - 21796 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1818732..1822858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111477.4 → NP_187254.1  NPK1-related protein kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187254.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22042, Q9SFG7
      UniProtKB/TrEMBL
      A0A178VLY7
      Conserved Domains (2) summary
      smart00220
      Location:68 → 330
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06606
      Location:67 → 330
      STKc_MAPKKK; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22042.1

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