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    PHP PLANT HOMOLOGOUS TO PARAFIBROMIN [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821831, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PHP
    Official Full Name
    PLANT HOMOLOGOUS TO PARAFIBROMIN
    Primary source
    TAIR:AT3G22590
    Locus tag
    AT3G22590
    See related
    Araport:AT3G22590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CDC73; PLANT HOMOLOGOUS TO PARAFIBROMIN
    Summary
    Encodes PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP), a homolog of human Paf1 Complex (Paf1C) subunit Parafibromin. Human Parafibromin assists in mediating output from the Wnt signaling pathway, and dysfunction of the encoding gene HRPT2 conditions specific cancer-related disease phenotypes. PHP resides in a ~670-kDa protein complex in nuclear extracts, and physically interacts with other known Paf1C-related proteins in vivo. Loss of PHP specifically conditioned accelerated phase transition from vegetative growth to flowering and resulted in misregulation of a very limited subset of genes that included the flowering repressor FLOWERING LOCUS C (FLC).
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    Genomic context

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    See PHP in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (8003898..8005902)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene 20S proteasome beta subunit D1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Potential role of Arabidopsis PHP as an accessory subunit of the PAF1 transcriptional cofactor. Park S, et al. Plant Signal Behav, 2011 Aug. PMID 21720211, Free PMC Article
    2. The Arabidopsis Paf1c complex component CDC73 participates in the modification of FLOWERING LOCUS C chromatin. Yu X, et al. Plant Physiol, 2010 Jul. PMID 20463090, Free PMC Article
    3. PLANT HOMOLOGOUS TO PARAFIBROMIN is a component of the PAF1 complex and assists in regulating expression of genes within H3K27ME3-enriched chromatin. Park S, et al. Plant Physiol, 2010 Jun. PMID 20363855, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PHP is an accessory subunit of Paf1C that promotes proper regulation of genes within H3K27me3-enriched chromatin.
      Title: Potential role of Arabidopsis PHP as an accessory subunit of the PAF1 transcriptional cofactor.
    2. CDC73 is required for high levels of FLC expression in a subset of autonomous-pathway-mutant backgrounds and functions both to promote activating histone modifications (H3K4me3) as well as preventing repressive ones (e.g. H3K27me3). [CDC73]
      Title: The Arabidopsis Paf1c complex component CDC73 participates in the modification of FLOWERING LOCUS C chromatin.
    3. PLANT HOMOLOGOUS TO PARAFIBROMIN represents the plant homolog of parafibromin, and interacts physically with other Paf1C components.
      Title: PLANT HOMOLOGOUS TO PARAFIBROMIN is a component of the PAF1 complex and assists in regulating expression of genes within H3K27ME3-enriched chromatin.
    Submit: New GeneRIF Correction

    General gene information

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    NM_113158.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase I core factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    PLANT HOMOLOGOUS TO PARAFIBROMIN
    NP_188898.1
    • PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP); CONTAINS InterPro DOMAIN/s: RNA polymerase II accessory factor, Cdc73 (InterPro:IPR007852); Has 502 Blast hits to 395 proteins in 198 species: Archae - 0; Bacteria - 0; Metazoa - 257; Fungi - 127; Plants - 42; Viruses - 0; Other Eukaryotes - 76 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8003898..8005902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113158.3 → NP_188898.1  PLANT HOMOLOGOUS TO PARAFIBROMIN [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188898.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LJ87
      UniProtKB/TrEMBL
      A0A178VJ60, A0A5S9XEY3
      Conserved Domains (2) summary
      COG5157
      Location:31 → 412
      CDC73; RNA polymerase II assessory factor [Transcription]
      pfam05179
      Location:252 → 407
      CDC73_C; RNA pol II accessory factor, Cdc73 family, C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LJ87.1

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