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    MIPS3 myo-inositol-1-phosphate synthase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830881, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MIPS3
    Official Full Name
    myo-inositol-1-phosphate synthase 3
    Primary source
    TAIR:AT5G10170
    Locus tag
    AT5G10170
    See related
    Araport:AT5G10170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMIPS3; myo-inositol-1-phosphate synthase 3; MYO-INOSITOL-1-PHOSTPATE SYNTHASE 3; T31P16.160; T31P16_160
    Summary
    myo-inositol-1-phosphate synthase isoform 3.Expressed in leaf, root and silique. Immunolocaliazation experiments with an antibody recognizing MIPS1, MIPS2, and MIPS3 showed endosperm localization.
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    Genomic context

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    See MIPS3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (3187277..3190321, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene K-box region and MADS-box transcription factor family protein Neighboring gene UPSTREAM OF FLC protein (DUF966) Neighboring gene Thioesterase superfamily protein Neighboring gene slufate transporter 2;1 Neighboring gene Major facilitator superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis. Fleet CM, et al. Plant Mol Biol, 2018 Jun. PMID 29777485
    2. The Arabidopsis thaliana Myo-inositol 1-phosphate synthase1 gene is required for Myo-inositol synthesis and suppression of cell death. Donahue JL, et al. Plant Cell, 2010 Mar. PMID 20215587, Free PMC Article
    3. D-myo-inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis. Luo Y, et al. Plant Cell, 2011 Apr. PMID 21505066, Free PMC Article
    4. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. works with MIPS1 AND MIPS2 to impact the overall synthesis of myo-inositol and overall inositol homeostasis
      Title: Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121055.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inositol-3-phosphate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in inositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    myo-inositol-1-phosphate synthase 3
    NP_196579.1
    • myo-inositol-1-phosphate synthase 3 (MIPS3); FUNCTIONS IN: binding, inositol-3-phosphate synthase activity, catalytic activity; INVOLVED IN: metabolic process, inositol biosynthetic process, phospholipid biosynthetic process; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Myo-inositol-1-phosphate synthase (InterPro:IPR002587), Myo-inositol-1-phosphate synthase, GAPDH-like (InterPro:IPR013021), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: myo-inositol-1-phosphate synthase 2 (TAIR:AT2G22240.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3187277..3190321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121055.4 → NP_196579.1  myo-inositol-1-phosphate synthase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196579.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LX12
      UniProtKB/TrEMBL
      A0A178UD42
      Conserved Domains (1) summary
      PLN02438
      Location:1 → 510
      PLN02438; inositol-3-phosphate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LX12.1

    Gene LinkOut

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