ECR1 E1 C-terminal related 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ECR1
Official Full Name: E1 C-terminal related 1
Primary source: TAIR:AT5G19180
Locus tag: AT5G19180
See related: Araport:AT5G19180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: E1 C-terminal related 1; T24G5.80; T24G5_80
Summary: Encodes a subunit of a RUB-activating enzyme analogous to the E1 ubiquitin-activating enzyme. ECR1 functions as a heterodimer with AXR1 to activate RUB, a ubiquitin-related protein.
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Genomic context

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See ECR1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 8

Sequence:: Chromosome: 5; NC_003076.8 (6453248..6456033)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AXR1 and AXL1 have similar abilities to function with E1 C-TERMINAL-RELATED1 (ECR1) in catalyzing RUB1 activation and RUB1-ECR1 thioester formation.
Title: AXR1-ECR1 and AXL1-ECR1 heterodimeric RUB-activating enzymes diverge in function in Arabidopsis thaliana.
The ecr1-1 mutant is resistant to the auxin-like compound indole-3-propionic acid, produces fewer lateral roots than wild type, displays reduced adult height, and stabilizes a reporter fusion protein that is degraded in response to auxin.
Title: Mutation of E1-CONJUGATING ENZYME-RELATED1 decreases RELATED TO UBIQUITIN conjugation and alters auxin response and development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MASC_STS15274 (e-PCR)
- UniSTS:258790

NM_121923.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NEDD8 activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables NEDD8 activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	NAS Non-traceable Author Statement more info	PubMed
enables ubiquitin-like modifier activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein neddylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein neddylation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: E1 C-terminal related 1

NP_568370.1

E1 C-terminal related 1 (ECR1); CONTAINS InterPro DOMAIN/s: Ubiquitin-activating enzyme repeat (InterPro:IPR000127), Ubiquitin-activating enzyme, E1, active site (InterPro:IPR018074), Ubiquitin-activating enzyme (InterPro:IPR019572), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040), E2 binding (InterPro:IPR014929); BEST Arabidopsis thaliana protein match is: SUMO-activating enzyme 2 (TAIR:AT2G21470.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

6453248..6456033

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001343592.1 → NP_001332355.1 E1 C-terminal related 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BGN7
NM_121923.4 → NP_568370.1 E1 C-terminal related 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568370.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65041, Q0WWG4, Q94A29

UniProtKB/TrEMBL

A0A5S9Y7S5

Conserved Domains (3) summary

cd01488
Location:48 → 343

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam00899
Location:36 → 341

ThiF; ThiF family

pfam08825
Location:350 → 439

E2_bind; E2 binding domain