LON2 lon protease 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: LON2
Official Full Name: lon protease 2
Primary source: TAIR:AT5G47040
Locus tag: AT5G47040
See related: Araport:AT5G47040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ABERRANT PEROXISOME MORPHOLOGY 10; APEM10; lon protease 2; MQD22.18; MQD22_18
Summary: Encodes a member of the Lon protease-like proteins (Lon1/At5g26860, Lon2/At5g47040, Lon3/At3g05780, Lon4/At3g05790). Lon is a multifunctional ATP-dependent protease which exists in bacteria, archaea and within organelles in eukaryotic cells. Lon proteases are responsible for the degradation of abnormal, damaged and unstable proteins.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Study identified the role of LON2 protease and the photorespiratory enzyme HPR1 in drought resistance.
Title: Using Co-Expression Analysis and Stress-Based Screens to Uncover Arabidopsis Peroxisomal Proteins Involved in Drought Response.
pexophagy is accelerated when the LON2 protease is disabled
Title: Mutation of the Arabidopsis LON2 peroxisomal protease enhances pexophagy.
atg2, atg3, and atg7 mutations suppressed lon2 defects in auxin metabolism and matrix protein processing and rescued the abnormally large size and small number of lon2 peroxisomes
Title: Disrupting autophagy restores peroxisome function to an Arabidopsis lon2 mutant and reveals a role for the LON2 protease in peroxisomal matrix protein degradation.
LON2- and autophagy-dependent pathways are interdependent, with the chaperone function of LON2 suppressing autophagic peroxisome degradation
Title: Interaction between chaperone and protease functions of LON2, and autophagy during the functional transition of peroxisomes.
LON2 is necessary for IBA-stimulated lateral root formation and for sustained matrix protein import into peroxisomes.
Title: Arabidopsis LON2 is necessary for peroxisomal function and sustained matrix protein import.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_124075.4

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lateral root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into peroxisome matrix, docking	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular organelle lumen	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

NP_568675.1

lon protease 2 (LON2); FUNCTIONS IN: in 6 functions; INVOLVED IN: protein import into peroxisome matrix, docking, growth, lateral root development; LOCATED IN: organelle lumen, peroxisome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), Peptidase S16, active site (InterPro:IPR008268), Peptidase S16, ATP-dependent protease La (InterPro:IPR004815), Peptidase S16, lon N-terminal (InterPro:IPR003111), Peptidase S16, Lon C-terminal (InterPro:IPR008269), ATPase, AAA+ type, core (InterPro:IPR003593), Regulator of G protein signalling superfamily (InterPro:IPR016137), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), Peptidase S16, Lon protease, C-terminal (InterPro:IPR001984); BEST Arabidopsis thaliana protein match is: lon protease 1 (TAIR:AT5G26860.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).