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    MES16 methyl esterase 16 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827371, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MES16
    Official Full Name
    methyl esterase 16
    Primary source
    TAIR:AT4G16690
    Locus tag
    AT4G16690
    See related
    Araport:AT4G16690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA METHYL ESTERASE 16; ATMES16; DL4370C; FCAALL.12; methyl esterase 16
    Summary
    Encodes a protein shown to have carboxylesterase activity, methyl IAA esterase activity, and methyl jasmonate esterase activity in vitro. This protein does not act on MeSA, MeGA4, or MEGA9 in vitro. Although MES16 is similar to MES17, a MeIAA hydrolase, two mes16 mutant lines (SALK_151578) and (SALK_139756) do not show altered sensitivity to MeIAA in root growth assays. MES16 transcripts appear to be more than 10-fold less abundant than those of MES17 in roots.
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    Genomic context

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    See MES16 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (9391964..9393650, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene auxin canalization protein (DUF828) Neighboring gene ncRNA Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene phosphatidylserine decarboxylase 1 Neighboring gene glycosyltransferase family protein 28 Neighboring gene Ribosomal protein L23/L15e family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of methylesterase family member 16 (MES16) from Arabidopsis thaliana. Li H, et al. Biochem Biophys Res Commun, 2016 May 20. PMID 27109476
    2. MES16, a member of the methylesterase protein family, specifically demethylates fluorescent chlorophyll catabolites during chlorophyll breakdown in Arabidopsis. Christ B, et al. Plant Physiol, 2012 Feb. PMID 22147518, Free PMC Article
    3. Cytochrome P450 CYP89A9 is involved in the formation of major chlorophyll catabolites during leaf senescence in Arabidopsis. Christ B, et al. Plant Cell, 2013 May. PMID 23723324, Free PMC Article
    4. Inactive methyl indole-3-acetic acid ester can be hydrolyzed and activated by several esterases belonging to the AtMES esterase family of Arabidopsis. Yang Y, et al. Plant Physiol, 2008 Jul. PMID 18467465, Free PMC Article
    5. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our biochemical studies reveal that MES16 has esterase activity with methyl-indole acetic acid as the substrate, and the catalytically essential role of Ser-87 has been demonstrated.
      Title: Crystal structure of methylesterase family member 16 (MES16) from Arabidopsis thaliana.
    2. data demonstrate that MES16 is an integral component of Chl breakdown in Arabidopsis and specifically demethylates Chl catabolites at the level of FCCs in the cytosol
      Title: MES16, a member of the methylesterase protein family, specifically demethylates fluorescent chlorophyll catabolites during chlorophyll breakdown in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_117770.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl indole-3-acetate esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl jasmonate esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl jasmonate esterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chlorophyll catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oxylipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    methyl esterase 16
    NP_193402.1
    • methyl esterase 16 (MES16); FUNCTIONS IN: hydrolase activity, acting on ester bonds, methyl jasmonate esterase activity, catalytic activity, methyl indole-3-acetate esterase activity; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: methyl esterase 18 (TAIR:AT5G58310.1); Has 1277 Blast hits to 1277 proteins in 292 species: Archae - 4; Bacteria - 558; Metazoa - 0; Fungi - 14; Plants - 596; Viruses - 3; Other Eukaryotes - 102 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9391964..9393650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117770.5 → NP_193402.1  methyl esterase 16 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23512
      UniProtKB/TrEMBL
      A0A654FQ46
      Conserved Domains (2) summary
      PLN02965
      Location:8 → 262
      PLN02965; Probable pheophorbidase
      PLN02211
      Location:12 → 256
      PLN02211; methyl indole-3-acetate methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23512.1

    Gene LinkOut

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