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    HEMD uroporphyrinogen-III synthase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817195, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEMD
    Official Full Name
    uroporphyrinogen-III synthase family protein
    Primary source
    TAIR:AT2G26540
    Locus tag
    AT2G26540
    See related
    Araport:AT2G26540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA UROPORPHYRINOGEN III SYNTHASE; ATDUF3; ATUROS; DOMAIN OF UNKNOWN FUNCTION 724 3; DUF3; T9J22.21; T9J22_21; UROPORPHYRINOGEN III SYNTHASE; UROS
    Summary
    Encodes a uroporphyrinogen-III synthase involved in tetrapyrrole biosynthesis. The protein localizes to the chloroplast. Member of the plant-specific DUF724 protein family. Arabidopsis has 10 DUF724 proteins. Loss of function mutant has a WT phenotype
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    Genomic context

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    See HEMD in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (11287308..11290361, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene AR781, pheromone receptor-like protein (DUF1645) Neighboring gene heme oxygenase 2 Neighboring gene phospholipase A 2A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the Arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen III synthase. Tan FC, et al. Biochem J, 2008 Mar 1. PMID 18042043
    2. Characterization of DUF724 gene family in Arabidopsis thaliana. Cao X, et al. Plant Mol Biol, 2010 Jan. PMID 19795213
    3. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that AtDuf3 genes were expressed in roots, leaves, shoot apical meristems, anthers and pollen grains. They may form homodimers or homopolymers, but did not interact with other members of the same family.
      Title: Characterization of DUF724 gene family in Arabidopsis thaliana.
    2. Identification of this gene in this plant by using functional complementation.
      Title: Identification and characterization of the Arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen III synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336073.1
    NM_001336074.1
    NM_128211.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables uroporphyrinogen-III synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uroporphyrinogen-III synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chlorophyll biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within uroporphyrinogen III biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uroporphyrinogen III biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    uroporphyrinogen-III synthase family protein
    NP_565625.1
    • HEMD; FUNCTIONS IN: uroporphyrinogen-III synthase activity; INVOLVED IN: uroporphyrinogen III biosynthetic process, porphyrin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase (InterPro:IPR003754); Has 1238 Blast hits to 1238 proteins in 600 species: Archae - 19; Bacteria - 1097; Metazoa - 0; Fungi - 1; Plants - 40; Viruses - 0; Other Eukaryotes - 81 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11287308..11290361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128211.4 → NP_565625.1  uroporphyrinogen-III synthase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48721, Q8LBE8, Q8RVZ2, Q8VZ12
      UniProtKB/TrEMBL
      A0A178VZ58, A0A5S9X1Q3, A0A654EWE3
      Conserved Domains (1) summary
      cd06578
      Location:67 → 304
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    2. NM_001336074.1 → NP_001324267.1  uroporphyrinogen-III synthase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZL4

    3. NM_001336073.1 → NP_001324266.1  uroporphyrinogen-III synthase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VZ58, A0A1P8AZK1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48721.2

    Gene LinkOut

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