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    HO2 heme oxygenase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817196, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HO2
    Official Full Name
    heme oxygenase 2
    Primary source
    TAIR:AT2G26550
    Locus tag
    AT2G26550
    See related
    Araport:AT2G26550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    heme oxygenase 2; T9J22.22; T9J22_22
    Summary
    Encodes a heme oxygenase-like protein lacking the conserved histidine residue at the active site that is usually involved in heme-iron coordination. It is unable to bind and degrade heme. Mutant analyses suggest a role in photomorphogenesis. The protein can bind the heme precursor, proto IX, which could be biologically significant and point to a role in the regulation of the two tetrapyrrole biosynthetic pathways.
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    Genomic context

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    See HO2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (11291148..11293575, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene AR781, pheromone receptor-like protein (DUF1645) Neighboring gene uroporphyrinogen-III synthase family protein Neighboring gene phospholipase A 2A Neighboring gene WEAK CHLOROPLAST MOVEMENT UNDER BLUE LIGHT-like protein (DUF827)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the haem oxygenase protein family in Arabidopsis thaliana reveals a diversity of functions. Gisk B, et al. Biochem J, 2010 Jan 15. PMID 19860740
    2. Multiple heme oxygenase family members contribute to the biosynthesis of the phytochrome chromophore in Arabidopsis. Emborg TJ, et al. Plant Physiol, 2006 Mar. PMID 16428602, Free PMC Article
    3. The Arabidopsis photomorphogenic mutant hy1 is deficient in phytochrome chromophore biosynthesis as a result of a mutation in a plastid heme oxygenase. Muramoto T, et al. Plant Cell, 1999 Mar. PMID 10072395, Free PMC Article
    4. The heme-oxygenase family required for phytochrome chromophore biosynthesis is necessary for proper photomorphogenesis in higher plants. Davis SJ, et al. Plant Physiol, 2001 Jun. PMID 11402195, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_128212.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables heme oxygenase (decyclizing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme oxygenase (decyclizing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme oxygenase (decyclizing) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phytochromobilin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    heme oxygenase 2
    NP_001189610.1
    • heme oxygenase 2 (HO2); CONTAINS InterPro DOMAIN/s: Haem oxygenase-like, multi-helical (InterPro:IPR016084), Haem oxygenase-like (InterPro:IPR016053), Haem oxygenase (decyclizing), plant (InterPro:IPR016951); BEST Arabidopsis thaliana protein match is: Plant haem oxygenase (decyclizing) family protein (TAIR:AT2G26670.1).
    NP_001189611.1
    • heme oxygenase 2 (HO2); CONTAINS InterPro DOMAIN/s: Haem oxygenase-like, multi-helical (InterPro:IPR016084), Haem oxygenase-like (InterPro:IPR016053), Haem oxygenase (decyclizing), plant (InterPro:IPR016951); BEST Arabidopsis thaliana protein match is: Plant haem oxygenase (decyclizing) family protein (TAIR:AT2G26670.1).
    NP_180223.2
    • heme oxygenase 2 (HO2); CONTAINS InterPro DOMAIN/s: Haem oxygenase-like, multi-helical (InterPro:IPR016084), Haem oxygenase-like (InterPro:IPR016053), Haem oxygenase (decyclizing), plant (InterPro:IPR016951); BEST Arabidopsis thaliana protein match is: Plant haem oxygenase (decyclizing) family protein (TAIR:AT2G26670.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11291148..11293575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202681.2 → NP_001189610.1  heme oxygenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48722
      UniProtKB/TrEMBL
      A0A178VUD0, A0A5S9X1L9, A0A654EXV3
      Conserved Domains (1) summary
      cd19165
      Location:127 → 297
      HemeO; heme oxygenase in eukaryotes and some bacteria

    2. NM_001336075.1 → NP_001325234.1  heme oxygenase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B2J8

    3. NM_001202682.1 → NP_001189611.1  heme oxygenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X1L9, A0A654EXV3, F4IUL9
      Conserved Domains (1) summary
      cd00232
      Location:75 → 312
      HemeO; Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This ...

    4. NM_128212.3 → NP_180223.2  heme oxygenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180223.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X1L9, A0A654EXV3, F4IUM0
      Conserved Domains (1) summary
      cd00232
      Location:75 → 352
      HemeO; Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48722.2

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