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    Ankrd6 ankyrin repeat domain 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500430, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankrd6provided by RGD
    Official Full Name
    ankyrin repeat domain 6provided by RGD
    Primary source
    RGD:1583731
    See related
    EnsemblRapid:ENSRNOG00000007110 AllianceGenome:RGD:1583731
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of JNK cascade. Predicted to act upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytoplasm and nucleus. Orthologous to human ANKRD6 (ankyrin repeat domain 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 61.1), Brain (RPKM 53.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankrd6 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (51999225..52139623, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47197981..47343183, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (48052610..48167568, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene midasin AAA ATPase 1 Neighboring gene LYR motif containing 2 Neighboring gene histidine-rich glycoprotein-like Neighboring gene gamma-glutamylamine cyclotransferase, pseudogene 3 Neighboring gene Ras-related GTP binding D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of rat Ankrd6 gene in silico. Katoh M, et al. Int J Mol Med, 2005 Feb. PMID 15647854
    2. The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. Haribaskar R, et al. Biochem Biophys Res Commun, 2009 Sep 11. PMID 19591803
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188478

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloroplast targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to chloroplast IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134969.1 → NP_001128441.1  ankyrin repeat domain-containing protein 6

      See identical proteins and their annotated locations for NP_001128441.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A0A0G2K8G5, B5DEH9, F7FKY4
      Conserved Domains (3) summary
      PLN02847
      Location:545 → 706
      PLN02847; triacylglycerol lipase
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      51999225..52139623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110550.2 → XP_038966478.1  ankyrin repeat domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8G5, B5DEH9, F7FKY4
      Conserved Domains (3) summary
      PLN02847
      Location:545 → 706
      PLN02847; triacylglycerol lipase
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]

    2. XM_017593571.3 → XP_017449060.1  ankyrin repeat domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8G5, B5DEH9, F7FKY4
      Conserved Domains (3) summary
      PLN02847
      Location:545 → 706
      PLN02847; triacylglycerol lipase
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]

    3. XM_039110548.2 → XP_038966476.1  ankyrin repeat domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8G5, B5DEH9, F7FKY4
      Related
      ENSRNOP00000105814.1, ENSRNOT00000128239.1
      Conserved Domains (3) summary
      PLN02847
      Location:545 → 706
      PLN02847; triacylglycerol lipase
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]

    4. XM_006237978.5 → XP_006238040.1  ankyrin repeat domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006238040.1

      UniProtKB/TrEMBL
      A0A0G2K8G5, B5DEH9, F7FKY4
      Related
      ENSRNOP00000061313.1, ENSRNOT00000065912.4
      Conserved Domains (3) summary
      PLN02847
      Location:545 → 706
      PLN02847; triacylglycerol lipase
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]

    5. XM_039110549.2 → XP_038966477.1  ankyrin repeat domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8G5, B5DEH9, F7FKY4
      Conserved Domains (3) summary
      PLN02847
      Location:545 → 706
      PLN02847; triacylglycerol lipase
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]

    6. XM_063288213.1 → XP_063144283.1  ankyrin repeat domain-containing protein 6 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A8Z9

    7. XM_063288208.1 → XP_063144278.1  ankyrin repeat domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8Z9
      Related
      ENSRNOP00000098716.1, ENSRNOT00000137740.1

    8. XM_063288212.1 → XP_063144282.1  ankyrin repeat domain-containing protein 6 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A8Z9
      Related
      ENSRNOP00000106482.1, ENSRNOT00000173159.1

    9. XM_063288209.1 → XP_063144279.1  ankyrin repeat domain-containing protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8Z9
      Related
      ENSRNOP00000074598.3, ENSRNOT00000088179.3

    10. XM_063288211.1 → XP_063144281.1  ankyrin repeat domain-containing protein 6 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JWC8
      Related
      ENSRNOP00000105781.1, ENSRNOT00000164914.1

    11. XM_039110547.2 → XP_038966475.1  ankyrin repeat domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8G5, B5DEH9, F7FKY4
      Conserved Domains (3) summary
      PLN02847
      Location:545 → 706
      PLN02847; triacylglycerol lipase
      PHA03095
      Location:29 → 265
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:41 → 72
      ANK; ANK repeat [structural motif]

    12. XM_063288215.1 → XP_063144285.1  ankyrin repeat domain-containing protein 6 isoform X8

    13. XM_063288214.1 → XP_063144284.1  ankyrin repeat domain-containing protein 6 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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